| Japanese |
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| Title | 虚血性心疾患における13NアンモニアポジトロンCTスタティック画像と壁運動の関係 |
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| Subtitle | 原著 |
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| Authors | 氷見寿治*, 伏島堅二*, 吉田勝哉**, 島田和浩*, 相生真吾*, 橘川志延*, 山内雅人*, 庭山博行*, 増田善昭* |
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| Authors(kana) | |
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| Organization | *千葉大学医学部第三内科, **放射線医学総合研究所 障害・臨床研究部 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 12 |
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| Page | 1341-1346 |
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| Year/Month | 1995/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患20例に13NアンモニアPET検査を行い, そのスタティック画像と壁運動を左室造影によって比較した. また, 同症例のうち15例に冠血行再建術を施行して成功し, それら15例の術後の壁運動の変化を検討した. 各症例の中隔, 前壁, 側壁の3セグメントを対象にそれぞれの運動をnormokinesis, hypokinesis, akinesis, dyskinesisに分類した. これらの壁運動において心筋内平均13N濃度はそれぞれ85±9.3%, 75±11%, 71±17%, 58±7.7%であり, 壁運動と関連を認めた. 冠血行再建術後, 壁運動の改善したセグメントの心筋内平均13N相対濃度は80±9.7%, 改善しなかったセグメントは67±8.3%で改善したセグメントの濃度が有意に高かった(p<0.05). 安静時13NアンモニアPET画像は虚血性心疾患においてその壁運動を反映し, 同時に冠血行再建術後の壁運動改善の有無を予測できる可能性を認めた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron emission tomography, 13N ammonia, Myocardial viability, Coronary artery disease, Ventricular function. |
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| English |
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| Title | Relationship between Static Images of 13N Ammonia Positron Emission Tomography and Left Ventricular Wall Motion in Patients with Coronary Artery Disease |
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| Authors | Toshiharu HIMI*, Kenji FUSEJIMA*, Katsuya YOSHIDA**, Kazuhiro SHIMADA*, Shingo AIOI*, Shinobu KITSUKAWA*, Masato YAMANOUCHI*, Hiroyuki NIWAYAMA*, Yoshiaki MASUDA* |
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| Authors(kana) | |
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| Organization | *Third Department of Internal Medicine, Chiba University, School of Medicine, **National Institute of Radiological Sciences |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 12 |
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| Page | 1341-1346 |
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| Year/Month | 1995/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Observed myocardial activities in static image of 13N ammonia positron emission tomography (PET) contains factors about not only myocardial blood flow but also wall motion, wall thickness and glutamine synthetase activity. Those factors may help to delineate myocardial viability in 13N ammonia static image. To assess the role of 13N ammonia static image in prediction of reversibility of regional wall motion abnormalities after revascularization, we studied 20 patients with coronary artery disease. Of these patients, 15 patients underwent successful coronary revascularization (8 PTCA, 7 CABG). Regional 13N concentration before revascularization was expressed as a percent of maximal myocardial concentration and compared with regional wall motion. Wall motion was assessed by visual analysis using left ventriculography. Regional myocardial 13N concentration in normal, hypokinetic, akinetic and dyskinetic segments was 85+-9.3% 75+-11%*, 71+-17%* and 58+-7.7%*#+, respectively (*p<0.05 vs. normal, #p<0.05 vs. hypokinesis, +p<0.05 vs. akinesis). The segments with functional improvement showed significantly higher concentration of 13N than those without functional recovery (80+-9.7% vs. 67+-8.3%, P<0.05). By using an optimized threshold value for normalized 13N activities, the sensitivity and specificity reached to 67% and 100%, respectively, to predict functional recovery. Our data suggested that myocardial 13N concentration in static PET image is closely related to the left ventricular wall motion in the patients with coronary artery disease and that it has a possible value of prediction of myocardial viability. |
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| Practice | Clinical medicine |
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| Keywords | Positron emission tomography, 13N ammonia, Myocardial viability, Coronary artery disease, Ventricular function. |
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