Japanese
Title123I-IMP SPECTを用いたmicrosphere modelに基づく局所脳血流量測定法 (簡便法) の精度の検討
Subtitle原著
Authors大久保真樹*, 小田野行男**, 高橋直也**, 高橋誠***, 大滝広雄**, 野口栄吉**, 笠原敏文**, 羽田野政義**, 横井孝司****
Authors(kana)
Organization*新潟大学医療技術短期大学部診療放射線技術学科, **新潟大学医学部放射線科, ***精神科, ****島津製作所医用技術部
Journal核医学
Volume32
Number12
Page1323-1331
Year/Month1995/12
Article原著
Publisher日本核医学会
Abstract「要旨」N-isopropyl-p-[123I]iodoamphetamine(IMP)を用いたmicrosphere modelに基づく局所脳血流量(rCBF)の測定(microsphere法)を行う場合, 一般には123I-IMP静注数十分後にSPECT撮像した画像を, 同時に測定した全脳カウントの変化率によって補正して利用する簡便法(conventional microsphere法)が用いられる場合が多い. この方法を2コンパートメントモデルに基づくシミュレーション解析により検討したところ, rCBFは10%以上の過大評価となることが分かった. 臨床データを用いた検討でも, conventional microsphere法がrCBFを過大評価する傾向がみられ, シミュレーション解析結果とよく適合した. しかし2コンパートメントモデルにおける値との線形相関はよく, またrCBF定量画像を作成したところmicrosphere法による画像と大きな違いはみられなかったことから, rCBFを過大評価することに留意すればconventional microsphere法は臨床的に有用な方法であると考えられた.
Practice臨床医学：一般
Keywords123I-IMP, Microsphere model, Regional cerebral blood flow, SPECT.
English
TitleA Study on Accuracy of rCBF Measurements Using the Conventional Microsphere Method with N-Isopropyl-p-[123I]Iodoamphetamine and SPECT
Subtitle
AuthorsMasaki OHKUBO*, Ikuo ODANO**, Naoya TAKAHASHI**, Makoto TAKAHASHI***, Hiroh OHTAKI**, Eikichi NOGUCHI**, Toshifumi KASAHARA**, Masayoshi HATANO**, Takashi YOKOI****
Authors(kana)
Organization*Department of Radiolgical Technology, College of Biomedical Technology, Niigata University, **Department of Radiology, Niigata University School of Medicine, ***Department of Psychiatry, Niigata University School of Medicine, *Department of Research for Medical Systems, Shimadzu Corporation
JournalThe Japanese Journal of nuclear medicine
Volume32
Number12
Page1323-1331
Year/Month1995/12
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]To evaluate the accuracy of conventional microsphere method for the measurement of regional cerebral blood flow (rCBF) based on the microsphere model with N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) and SPECT, we performed simulation analysis and clinical studies. Although the microsphere method requires early SPECT scan at a few minutes after injection of the tracer for the accurate measurement of rCBF, the conventional microsphere method, which is generally used, requires more delayed SPECT scan with long scan-duration. In the conventional microsphere method, the delayed SPECT image is corrected to the image at a few minutes after injection of the tracer by using the monitored entire brain activity. By the simulation analysis based on the 2-compartment model (influx ; K1 and outflux ; k2) using the input function and the entire brain activity obtained from eight subjects respectively, it was found that the conventional microsphere method overestimated the rCBF in the practical range of rCBF and Vd (=K1/k2) given in the 2-compartment model. When the values of rCBF and Vd in the 2-compartment model were given at 0.5 (ml/g/min) and 30(ml/g) respectively, the rate of overestimation of rCBF by the conventional microsphere method was determined to be 17.3+-0.7% (mean+-S.D.). Also in clinical studies for eight subjects, the conventional microsphere method overestimated the rCBF compared with those evaluated by non-linear least squares fitting (NLLSF) analysis based on the 2-compartment model. Those results agreed well with the simulation analysis, suggesting the validity of the simulation. The rCBF values clinically estimated by the conventional method were, however, significantly correlated with those calculated by NLLSF analysis, and there were not so much difference between the two quantitative rCBF images obtained by the conventional microsphere method and the microsphere method. Therefore, we conclude that the conventional microsphere method is clinically useful in spite of the overestimation of rCBF.
PracticeClinical medicine
Keywords123I-IMP, Microsphere model, Regional cerebral blood flow, SPECT.

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