| Japanese |
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| Title | Shy-Drager症候群患者における立位負荷時の脳血流変化の検討 |
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| Subtitle | 短報 |
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| Authors | 五味達哉*, 寺田一志*, 桑島章*, 平松慶博*, 浜崎千裕**, 上原英夫**, 木下真男***, 松田博史**** |
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| Authors(kana) | |
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| Organization | *東邦大学医学部第二放射線科, **東邦大学大橋病院放射線部, ***東邦大学医学部第四内科, ****国立精神神経センター武蔵病院放射線科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1255-1258 |
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| Year/Month | 1995/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-HMPAOによるRI angiographyにPatlak Plot法を応用し, 体位による脳血流の変化を検討した. Shy-Drager症候群患者4例および起立性低血圧を認めない他疾患の2例に対して, 99mTc-HMPAOによる脳血流SPECTを施行する際, RI angiographyの撮像を追加した. まず臥位にてbaseline studyを行い, その後およそ1週間以内に立位あるいは坐位でのstudyを行った. いずれも大動脈と脳に関心領域をとり, 各々の時間放射能曲線を得た後, Patlak Plot法を用いて, Brain Perfusion Index (BPI) を算出した. Shy-Drager症候群4例のうち, 起立性低血圧に対し脈拍数の増加による代償がみられた1例を除き, 立位負荷によりBPIは平均で21%減少した. 他疾患例には明らかなBPIの減少はみられなかった. 坐位や立位でも脳血流定量化の可能な本法は体位による脳血流の変化の評価に有用と思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Shy-Dragers syndrome, 99mTc-HMPAO, CBF. |
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| English |
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| Title | Quantitative Changes in cerebral Blood Flow of Shy-Drager Syndrome Induced by Upright Position : Assessment by 99mTc-HMPAO |
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| Authors | Tatsuya GOMI*, Hitoshi TERADA*, Akira KUWAJIMA*, Yoshihiro HIRAMATSU*, Kazuhiro HAMAZAKI**, Hideo UEHARA**, Masao KINOSHITA***, Hiroshi MATSUDA**** |
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| Authors(kana) | |
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| Organization | *Department of Second Radiology, Toho University School of Medicine, **Department of Radiology, Ohashi Hospital, Toho University School of Medicine, ***Department of Fourth Internal Medicine, Toho University School of Medicine, ****Division of Radiology and Nuclear Medicine, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1255-1258 |
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| Year/Month | 1995/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We assessed orthostatic changes of cerebral blood flow (CBF) in 4 patients with Shy-Drager syndrome. Brain perfusion index (BPI) was measured by 99mTc-hexamethylpropylene amine oxime (99mTc-HMPAO). Cerebral angiography using aortic time-activity curve as an input function BPI values in supine and upright positions in Shy-Drager syndrome were compared with those in 2 cerebrovascular disease patients without orthostatic hypotension. BPI values in the upright position were significantly decreased in patients with Shy-Drager syndrome as compared with these in the supine position. No significant decrease in BPI was noted in the patients without orthostatic hypotension. These results suggest that the BPI measurement by 99mTc-HMPAO cerebral angiography is useful for the noninvasive evaluation of the orthostatic changes of the CBF. |
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| Practice | Clinical medicine |
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| Keywords | Shy-Dragers syndrome, 99mTc-HMPAO, CBF. |
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