| Japanese |
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| Title | 全身タリウムシンチグラフィで明瞭な骨格の描出を認めた前立腺癌びまん性骨転移例 |
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| Subtitle | 症例報告 |
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| Authors | 津布久雅彦*, 林三進*, 伊東邦子*, 金子稜威雄*, 嶋田守男*, 赤坂喜清**, 草間香*, 木暮喬* |
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| Authors(kana) | |
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| Organization | *東邦大学医学部第一放射線医学教室, **第二病理学教室 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1249-1253 |
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| Year/Month | 1995/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」前立腺癌びまん性骨転移例において塩化タリウムの骨髄集積による明瞭な骨格の描出を認めた. 臨床的には前立腺に異常を認めなかったが, 早期胃癌の術後に白血球減少をきたしたことを契機とし, 骨髄生検および前立腺生検により確定診断された. 骨X線像での造骨性骨変化は軽微で, 骨髄生検組織でも腫瘍細胞浸潤増殖に伴う骨梁の破壊, 反応性の骨梁の肥厚を呈さない骨梁間型の骨転移と考えられた. 前立腺癌の骨転移に伴う骨組織の形態学的変化は造骨型が大半をしめ, 広範囲に骨梁を保ったまま浸潤増殖するものは比較的まれとされている. 生理的には骨集積を認めない塩化タリウムを悪性腫瘍例に適用することにより, 非侵襲的な骨髄転移診断への一助になりうるものと考える. |
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| Practice | 臨床医学：一般 |
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| Keywords | Prostatic cancer, Diffuse bone metastases, Bone marrow, 201Tl-chloride, Whole body imaging. |
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| English |
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| Title | Clear Skeletal Visualization on Whole Body 201Tl-chloride Scintigraphy : A Case of Prostatic Cancer with Diffuse Bone Metastases |
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| Authors | Masahiko TSUBUKU*, Sanshin HAYASHI*, Kuniko ITOH*, Itsuo KANEKO*, Morio SHIMADA*, Yoshikiyo AKASAKA**, Kaoru KUSAMA*, Takashi KOGURE* |
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| Authors(kana) | |
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| Organization | *First Department of Radiology, **Second Department of Pathology, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1249-1253 |
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| Year/Month | 1995/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A 70-yr-old man who was diagnosed as early gastric cancer showed leukocytopenia after total gastrectomy. Osteosclerotic findings on radiography were not remarkable. 99mTc-HMDP bone scintigraphy showed diffusely increased uptake in the axial skeleton, but visualization of the kidney and urinary bladder was apparent. However, whole body 201Tl-chloride scintigraphy showed diffuse abnormal visualization of axial skeleton. Physical and ultrasonographic examination indicated no abnormality in prostate. Afterward, further investigation, including bone marrow biopsy and immunohistochemical study, confirmed the diagnosis of bone metastasis from prostatic cancer. Microscopically, metastatic tumor cells were located in the intertrabecular space. Furthermore, no osteoclastic bone resorption or new trabecular bone formation was seen in this biopsy specimen. These findings suggest that whole body 201Tl-chloride scintigraphy can be a useful non-invasive diagnostic tool to investigate patients with suspicious malignancy in the bone marrow. |
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| Practice | Clinical medicine |
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| Keywords | Prostatic cancer, Diffuse bone metastases, Bone marrow, 201Tl-chloride, Whole body imaging. |
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