| Japanese |
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| Title | 脳梗塞亜急性期の "luxury perfusion" における99mTc-ECD dynamic SPECT |
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| Subtitle | 原著 |
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| Authors | 小笠原邦昭*, 藤原悟*, 吉本高志** |
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| Organization | *広南病院脳神経外科, **東北大学医学部脳神経外科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1241-1247 |
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| Year/Month | 1995/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳梗塞亜急性期のluxury perfusion例をはじめとした高灌流を示す病変に対し99mTc-ECDによるdynamic SPECTを施行し, その初期脳内薬物動態について検討した. 急性脳腫脹に対する外減圧術後, 発作中のてんかんなどの組織障害のない高灌流域においては, 正常血流域と同様のtime activity curveを示し, 病変部と対側正常部のカウント比も経時的に変化せず, トレーサ投与後極早期からlate static imageまで一定の値を示した. 一方, luxury perfusion域においてはトレーサの投与後1-2分で健側と同等以上の集積を示した後急速な洗い出しを示し, さらに投与後4-5分には緩徐な洗い出しに変わった. この結果より99mTc-ECDは投与後極早期には脳血流増加に応じて一旦は脳組織に入ると考えられた. しかし, 脳内保持機構の低下により脳組織内には保持されず, ピーク後急速な洗い出しを示すものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ethyl cysteinate dimer (99mTc-ECD), Luxury perfusion, Dynamic SPECT. |
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| English |
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| Title | 99mTc-ECD Dynamic SPECT in "Luxury Perfusion" of Subacute Stroke |
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| Subtitle | |
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| Authors | Kuniaki OGASAWARA*, Satoru FUJIWARA*, Takashi YOSHIMOTO** |
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| Authors(kana) | |
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| Organization | *Department of Neurosurgery, Kohnan Hospital, **Department of Neurosurgery, Tohoku University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1241-1247 |
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| Year/Month | 1995/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate the cerebral pharmacokinetics of 99mTc-ethyl cysteinate dimer (99mTc-ECD) at blood flow levels beyond the normal range, we investigated "luxury perfusion" in subacute stroke, ictal hyperperfusion in epilepsy and post-decompressive hyperemia in head trauma. All 7 patients showed a hyperactive area on SPECT studies using 99mTc-HM-PAO. 99mTc-ECD static image demonstrated a hyperactive area in both epilepsy and head trauma, and a hypoactive area in "luxury perfusion." On the dynamic SPECT of 99mTc-ECD in both epilepsy and head trauma, brain distribution of the tracer was determined within 2 min. postinjection and remained stable for up to 1 hour ; however, "luxury perfusion" area showed a change from initial hyperactivity to late hypoactivity with the passage of time. The time activity curve in "luxury perfusion" area demonstrated a steep decrease of counts/pixel for up to 4-5 minutes postinjection, and a moderate decrease in the following phase. The early wash-out mechanism of 99mTc-ECD from "luxury perfusion" area can be described by a biexponential function including an initial steep decrease representing the rapid loss of the lipophilic complexes which were not metabolized in injured brain tissue. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ethyl cysteinate dimer (99mTc-ECD), Luxury perfusion, Dynamic SPECT. |
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