| Japanese |
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| Title | 単検出器回転型ガンマカメラと123I-IMPを用いた局所脳血流定量法の時間短縮と分割投与Diamox負荷への応用 |
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| Subtitle | 原著 |
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| Authors | 井上武*, 藤岡弘良**, 赤宗明久*, 棚田修二***, 濱本研*** |
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| Authors(kana) | |
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| Organization | *松山市民病院放射線科, **放射線室, ***愛媛大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1217-1226 |
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| Year/Month | 1995/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-p-[123I]iodoamphetamine(123I-IMP)と単検出器回転型ガンマカメラを用いた持続動脈採血法による局所脳血流定量法をSPECT撮像時期を早めることで検査所要時間を短縮する方法(modified early法)を考案した. 123I-IMP投与後, 脳放射能が直線的に増加する7〜25分の間にガンマカメラを反復回転してSPECTデータを収集しその前後および5分時のplanar像と5分間の持続動脈採血より得られた入力カウントからマイクロスフェアモデルに基づき局所脳血流値を算出した. 測定値は投与後約30分以降にSPECTデータを収集する従来の方法とよく相関(r=0.951)した. さらに本法を用いて123I-IMP2回分割投与による安静時およびDiamox負荷脳血流定量法への応用を考案し, 同日中に安静時脳血流と脳循環予備能の定量評価が可能であった. 本法は広く行われているマイクロスフェア法を時間短縮できるだけでなく分割投与にも応用でき, かつ脳からの洗い出しの影響の低減された局所脳血流値を算出する方法である. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, SPECT, Regional cerebral blood flow, Microsphere model, Acetazolamide. |
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| English |
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| Title | A Time-Saving Approach for Quantifying Regional Cerebral Blood Flow and Application to Split-Dose Method with 123I-IMP SPECT Using a Single-Head Rotating Gamma-Camera |
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| Subtitle | |
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| Authors | Takeshi INOUE*, Hiroyoshi FUJIOKA**, Akihisa AKAMUNE*, Syuji TANADA***, Ken HAMAMOTO*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Section of Radiology, Matsuyama Shimin Hospital, ***Department of Radiology, Ehime University, Faculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1217-1226 |
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| Year/Month | 1995/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We have proposed a modified early method, which can shorten the total time required for the quantitative regional cerebral blood flow (rCBF) measurement with N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) using single-head rotating gamma-camera and the continuous arterial sampling method. Between 7 to 25 minutes after the intravenous injection of 123I-IMP, brain activity in creases linearly, the SPECT data acquisition is being performed, and during which detector is rotating continuously. Then the rCBF values based on the microsphere model were calculated using the planar images obtained before and after the above acquisition and 5 min after the injection, and input counts obtained by the continuous arterial sampling. A good correlation (r=0.951) was observed between the rCBF values obtained by this method and the traditional method, in which the SPECT data acquisition started about 30 min after injection. Appling this method to the quantitative rCBF measurements at rest and during stress with Diamox by the split dose method of 123I-IMP, we could evaluate the rCBF at rest and cerebral perfusion reserve in the same day. We conclude that this method can shorten the total time required for the standard normal microsphere method and can be applied to the split dose method, and this method provide the rCBF values not so much affected by washout of the tracer from the brain. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, SPECT, Regional cerebral blood flow, Microsphere model, Acetazolamide. |
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