| Japanese |
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| Title | 99mTc MAG3による腎機能評価 - Bubeck法によるtubular extraction rate定量を中心に - |
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| Subtitle | 原著 |
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| Authors | 山崎哲郎*, 丸岡伸*, 坂本澄彦* |
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| Organization | *東北大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1199-1206 |
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| Year/Month | 1995/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc MAG3は従来の製剤と比較して優れた画像が得られる新しい動態腎シンチグラフィ用製剤であり, また, 従来の製剤同様, 腎機能の定量的評価も可能である. 1回採血による簡便な定量法であるBubeck法により, 31名の患者のTERを算出し, 一般臨床検査値, 他の核医学的腎機能指標と対比し, その臨床的有用性を検討した. Bubeck法により算出されたTERはパラアミノ馬尿酸クリアランス, 131I OIHの同時投与で測定された有効腎血漿流量, 2compartment modelから算出された血漿クリアランス値などと良好な相関を示し, 臨床的に導入も容易であることから, 有用な腎機能指標であると考えられた. 「I. はじめに」新たな腎動態シンチグラフィ用製剤として, 99mTc mercaptoacetyltriglycine(MAG3)が本邦でも使用可能となり, 従来の製剤に優る画質を供しうる特徴を持った薬剤として期待されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MAG3, Dynamic renal scintigraphy, Renal function, Tubular extraction rate(TER). |
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| English |
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| Title | Quantification of Renal Function with 99mTc-MAG3 - Quantification of Tubular Extraction Rate using Bubeck's Method - |
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| Authors | Tetsuro YAMAZAKI, Shin MARUOKA, Kiyohiko SAKAMOTO |
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| Authors(kana) | |
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| Organization | Department of Radiology, Tohoku University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 11 |
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| Page | 1199-1206 |
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| Year/Month | 1995/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]99mTc-mercaptoacetyltriglycine (MAG3) is a new agent for dynamic renal scintigraphy. It provides not only superior quality of imaging to conventional agents such as 131I-orthoiodohippurate or 99mTc-demethylenetriaminepantaacetic acid but also quantification of renal function as do the latter agents. The aim of the present study was to evaluate the value of the tubular extraction rate (TER) using 99mTc-MAG3 calculated by Bubeck's method, a simple technique for quantifying renal function. In 31 patients with renal disorders, we compared the TER thus obtained with laboratory data, plasma paraaminohippurate clearance, effective renal plasma flow calculated by Tauxe's method, and plasma 99mTc-MAG3 clearance calculated according to the two-compartment model. TER was easily applicable in clinical settings, and showed close parallels with the other indexes of renal function. We believe, therefore, that it can serve as a useful parameter of renal function. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MAG3, Dynamic renal scintigraphy, Renal function, Tubular extraction rate(TER). |
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