| Japanese |
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| Title | 軽労作負荷β-メチル-p- (123I) -ヨードフェニルペンタデカン酸 (123I-BMIPP) 心筋シンチグラフィが心筋虚血の検出に有用であった2症例 |
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| Subtitle | 症例報告 |
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| Authors | 伊藤康志*, 植原敏勇*, 福地一樹*, 辻村英一郎*, 両角隆一**, 楠岡英雄*, 西村恒彦* |
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| Authors(kana) | |
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| Organization | *大阪大学医学部トレーサ情報解析, **第一内科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 10 |
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| Page | 1117-1123 |
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| Year/Month | 1995/10 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心筋脂肪酸代謝は虚血の影響を受け易い. 心筋脂肪酸代謝を反映するトレーサである123I-BMIPP(BM)を用いれば, 軽労作負荷により冠動脈罹患部位のBM心筋摂取は正常部位に比し低下すると推定される. そこで軽労作負荷BM心筋シンチを考案し, 心筋虚血の検出に有用と考えられた2症例を経験したので報告する. 軽労作負荷は自転車エルゴメータにて25〜50Wの運動負荷を行い, 負荷3分目にBMを投与しその後7分間同負荷を継続した. 症例1は川崎病の12歳男性で, 左前下行枝#6に90%狭窄を認めた. 運動負荷201Tl心筋シンチではRI集積低下を指摘できなかった前側壁に, 軽労作負荷BMシンチにてRI集積低下を認めた. 症例2は3枝病変を認めた64歳女性で, 軽労作負荷123I-BMIPPシンチにより, 運動負荷99mTc-sestamibiと同等の心筋虚血の検出を行えた. したがって軽労作負荷BMシンチは, 心筋虚血を鋭敏に検出できる可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Mild exercise, 123I-BMIPP, Myocardial ischemia. |
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| English |
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| Title | Experience with Mild Exercise 123I-BMIPP Myocardial Imaging in Two Cases of Ischemic Heart Disease |
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| Authors | Yasushi ITO*, Toshiisa UEHARA*, Kazuki FUKUCHI*, Eiichiro TSUJIMURA*, Takakazu MOROZUMI**, Hideo KUSUOKA*, Tsunehiko NISHIMURA* |
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| Authors(kana) | |
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| Organization | *Division of Tracer Kinetics, Biochemical Research Center, **Department of First Internal Medicine, Osaka University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 10 |
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| Page | 1117-1123 |
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| Year/Month | 1995/10 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | During mild to moderate ischemia, glycolytic flux is enhanced and free fatty acid uptake is reduced in proportion to the reduction in mitochondrial metabolism. We considered that mild exercise may induce the reduction of 123I-BMIPP, reflecting myocardial fatty acid metabolism, in ischemic myocardium compared to normal myocardium. Therefore, mild exercise 123I-BMIPP myocardial imaging was carried out to detect myocardial ischemia in 2 cases of ischemic heart disease. Mild exercise was performed using a bicycle ergometer with 25-50 W loading. At seven minutes before cessation of exercise, 111 MBq of 123I-BMIPP was injected. Case 1 was a 12 year-old boy with Kawasaki's disease. The study showed a reduction of mild exercise 123I-BMIPP uptake in the anteroseptal wall. In contrast, stress 201Tl myocardial imaging did not show perfusion defect in the anteroseptal wall. Case 2 was a 64 year-old female with triple vessels disease. Mild exercise 123I-BMIPP myocardial imaging showed similar with those of stress 99mTc-sestamibi. We conclude that mild exercise 123I-BMIPP myocardial SPECT may be a sensitive method to detect myocardial ischemia. |
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| Practice | Clinical medicine |
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| Keywords | Mild exercise, 123I-BMIPP, Myocardial ischemia. |
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