| Japanese |
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| Title | 降圧治療により退縮とともに123I-MIBG心筋シンチグラフィ所見の改善を認めた高血圧性心肥大の1例 |
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| Subtitle | 症例報告 |
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| Authors | 森本聡*, 寺田幸治*, 計良夏哉*, 里田雅彦*, 井上啓司*, 立川弘孝*, 加藤周司*, 杉原洋樹**, 武田和夫*** |
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| Authors(kana) | |
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| Organization | *朝日大学村上記念病院内科, **京都府立医科大学放射線科, ***第二内科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 10 |
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| Page | 1107-1112 |
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| Year/Month | 1995/10 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」7か月間の降圧治療により左室肥大の退縮と123I-metaiodobenzylguanidine(MIBG)心筋シンチグラフィ所見の改善を認めた高血圧性心肥大の1例を報告する. 症例は58歳男性で, 7年来放置していた高血圧歴がある. 頭痛を主訴に当科を受診したが, 本態性高血圧症および高血圧性心肥大と診断された. 7か月間の降圧治療により心電図上の左室肥大所見は消失し, 心臓超音波検査上肥大の退縮を認めた. 一方, MIBG心筋シンチグラフィでは下後壁の集積低下所見, 心臓縦隔比および心臓全体のクリアランスがいずれも改善した. 高血圧性心肥大の退縮の機序には諸説があり不明な点も多いが, 交感神経系賦活化の抑制の関与も推定されている. MIBG心筋シンチグラフィ所見が改善したことより本症例の肥大退縮に心臓交感神経機能異常の改善が関与している可能性が示唆された. 本症例はMIBG心筋シンチグラフィが高血圧性心肥大の退縮の病態の解明に寄与する可能性を示唆する貴重な症例と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Hypertensive hypertrophy, Antihypertensive therapy, Regression, 123I-MIBG, Cardiac sympathetic nervous dysfunction. |
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| English |
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| Title | A Case of Hypertensive Hypertrophy in which Both Regression of Hypertrophy and Improvement of the Abnormalities in Iodine-123-Metaiodobenzylguanidine (MIBG) Myocardial Imagings were Observed after Antihypertensive Therapy |
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| Subtitle | Case Reports |
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| Authors | Satoshi MORIMOTO*, Kouji TERADA*, Natsuya KEIRA*, Masahiko SATODA*, Keiji INOUE*, Hirotaka TATSUKAWA*, Shuji KATOH*, Hiroki SUGIHARA**, Kazuo TAKEDA*** |
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| Authors(kana) | |
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| Organization | *Department of Medicine, Murakami Memorial Hospital, Asahi University, **Department of Radiology, Kyoto Prefectural University of Medicine, ***Second Department of Medicine, Kyoto Prefectural University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 10 |
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| Page | 1107-1112 |
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| Year/Month | 1995/10 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | A case of hypertensive hypertrophy is described in which both regression of hypertrophy and improvement of the abnormalities in iodine-123-metaiodobenzylguanidine (MIBG) myocardial imagings were seen after 7 months of antihypertensive therapy. A 58-year-old man was diagnosed as having essential hypertension and hypertensive hypertrophy. The patient was treated with antihypertensive drugs and showed regression of left ventricular hypertrophy on electrocardiograms and echocardiograms. MIBG observations made before and after antihypertensive therapy showed increased heart-to-mediastinum activity ratio and decreased cardiac washout ratio. Despite the many theories addressing the mechanisms of regression of left ventricular hypertrophy, the process is still unclear. In the present case, the improvement of cardiac sympathetic nervous dysfunction might have been related to the regression of left ventricular hypertrophy because the abnormality in MIBG images improved. MIBG, therefore, may be helpful in clarifying the mechanisms of the regression of hypertensive hypertrophy. |
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| Practice | Clinical medicine |
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| Keywords | Hypertensive hypertrophy, Antihypertensive therapy, Regression, 123I-MIBG, Cardiac sympathetic nervous dysfunction. |
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