| Japanese |
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| Title | 冠攣縮性狭心症における123I-BMIPP心筋シンチグラフィの検討 |
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| Subtitle | 原著 |
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| Authors | 伊藤一貴*, 杉原洋樹**, 寺田幸治*, 谷口洋子*, 大槻克一*, 松本雄賀*, 宮崎浩志*, 中川達哉*, 東秋弘*, 前田知穂**, 中川雅夫* |
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| Organization | *京都府立医科大学第二内科, **放射線科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 10 |
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| Page | 1099-1106 |
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| Year/Month | 1995/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」冠攣縮性狭心症における123I-BMIPP心筋シンチグラフィの臨床的有用性を検討した. 冠攣縮性狭心症20例を対象とし, 安静時123I-BMIPP心筋SPECTと運動負荷201Tl心筋SPECTを施行した. 再構成したSPECT画像の左室を17領域に分割し, 各領域におけるBMIPPおよびTlの集積低下程度を半定量的に評価し, 安静時123I-BMIPP心筋SPECTと運動負荷201Tl心筋SPECTの冠攣縮性狭心症の検出能を検討した. また, BMIPPの集積低下程度と罹病期間, 最終発作からの期間, 発作回数, 左室駆出率, 局所壁運動異常との関連を検討した. 安静時123I-BMIPP心筋SPECTでは20例中14例(70%)で集積低下を認めた. 運動負荷201Tl心筋SPECTでは20例中3例(15%)で集積低下を示したが, いずれの症例でも遅延像では再分布がみられた. BMIPPの集積低下程度は局所壁運動異常の程度および最終発作からの期間と関連し, 罹病期間, 左室駆出率および発作回数とは関連しなかった. 123I-BMIPP心筋シンチグラフィは冠攣縮による心筋虚血障害歴を"memory"した像を呈し, 冠攣縮性狭心症の診断および病態把握に有用であることが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-BMIPP scintigraphy, Vasospastic angina, Exercise 201Tl scintigraphy. |
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| English |
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| Title | Assessment of Myocardial Fatty Acid Metabolism in Patients with Vasospastic Angina Using 123I-BMIPP Myocardial SPECT |
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| Subtitle | Original Articles |
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| Authors | Kazuki ITO*, Hiroki SUGIHARA**, Kouji TERADA*, Katsushige MATSUMOTO*, Yoko TANIGUCHI*, Katsuichi OHTSUKI*, Hiroshi MIYAZAKI*, Tatsuya NAKAGAWA*, Akihiro AZUMA*, Tomoho MAEDA**, Masao NAKAGAWA* |
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| Authors(kana) | |
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| Organization | *Second Department of Medicine, Kyoto Prefectural University of Medicine, **Department of Radiology, Kyoto Prefectural University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 10 |
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| Page | 1099-1106 |
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| Year/Month | 1995/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Myocardial perfusion and fatty acid metabolism may be unpaired in the patients of vasospastic angina (VSA), because abnormal regional wall motion of left ventricle has been shown in some cases of VSA without apparent history of myocardial infarction. To study the clinical utility of 123I-BMIPP scintigraphy in diagnosis of myocardial ischemia in VSA, both 123I-BMIPP (rest) and 201Tl (exercise) SPECT were performed in the 20 patients of VSA diagnosed by coronary angiography. Defect scores were calculated visually from the 17 segments of myocardial images and were compared with patient's anginal history, period from last attack, numbers of attack, left ventricular (LV) ejection fraction and severity of regional LV wall motion abnormality. 123I-BMIPP SPECT images showed decreased tracer uptake in 14 cases of 20 (70%) VSA patients. Exercise 201Tl SPECT images showed decreased tracer uptake in 3 cases of 20 (15%) of patients. Severity of regional LV wall motion abnormality was correlated with defect score of BMIPP. Though total defect score of BMIPP did not correlate with patient's anginal history, number of symptoms and LV ejection fraction, correlated inversely with period from last attack. It was suggested that 123I-BMIPP myocardial SPECT images in VSA patients showed "memories" of myocardial ischemic damages induced by vasospasm. In summary, 123I-BMIPP myocardial SPECT images could be a useful test for diagnosis and evaluation of VSA. |
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| Practice | Clinical medicine |
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| Keywords | 123I-BMIPP scintigraphy, Vasospastic angina, Exercise 201Tl scintigraphy. |
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