| Japanese |
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| Title | 健常者および虚血性心疾患患者における運動負荷後の左室駆出率オーバーシュートの成立機序 - 99mTc運動負荷心プールシンチグラフィによる検討 - |
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| Subtitle | 原著 |
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| Authors | 久保田幸夫*, 飯塚利夫*, 磯部直樹*, 長岡秀樹*, 今井進*, 鈴木忠** |
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| Authors(kana) | |
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| Organization | *群馬大学医学部第二内科, **群馬大学医療短期大学部 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 10 |
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| Page | 1079-1088 |
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| Year/Month | 1995/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」運動負荷終了後に安静時に比し左室駆出率(LVEF)が増加するオーバーシュート現象(OS)の機序を明らかにするため, Swan-Ganzカテーテル挿入下に, 健常者16例および虚血性心疾患患者(CAD)15例を対象として, 運動負荷99mTc心プールシンチグラフィ(RNVG)を施行し, 安静時, 運動負荷時および負荷後回復期のLVEFと血行動態諸指標の関係を検討した. 健常群ではLVEFは安静時に比し最大負荷時に有意に増加し, 回復期3分ではさらに増加してOSが認められた. また, CAD群のLVEFは, 最大負荷時には安静時に比し有意に減少したが, 回復期3分では安静時に比し有意に増加してOSを示した. OS時の拡張末期容積は, 健常群では安静時に比し減少したが, CAD群では不変であり, 収縮末期容積は両群ともに安静時に比し有意に減少した. OS時の末梢血管抵抗は, 両群ともに負荷時に比し有意に上昇した. 心収縮性の指標である収縮期血圧/収縮末期容積は, OS時に両群とも安静時に比し増加した. CAD群の10/15例は負荷後回復期3分には壁運動異常は消失していた. 健常群およびCADにおける負荷後回復期のLVEFのOSは, 前負荷, 後負荷の変化および心筋虚血よりの回復よりも心収縮性の亢進を反映していると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Exercise radionuclide ventriculography, Left ventricular ejection fraction, Overshoot, Coronary artery disease. |
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| English |
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| Title | Mechanism of Overshoot Elevation of Left Ventricular Ejection Fraction during Recovery after Exercise in Normal Subjects and Patients with Coronary Artery Disease, Assessed by 99mTc Exercise Radionuclide Ventriculography |
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| Subtitle | Original Articles |
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| Authors | Sachio KUBOTA*, Toshio IIZUKA*, Naoki ISOBE*, Hideki NAGAOKA*, Susumu IMAI*, Tadashi SUZUKI** |
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| Authors(kana) | |
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| Organization | *Second Department of Internal Medicine, Gunma University, School of Medicine, **College of Medical Care and Technology, Gunma University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 10 |
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| Page | 1079-1088 |
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| Year/Month | 1995/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | An "overshoot" (OS) elevation of ejection fraction above resting levels has been demonstrated during recovery after exercise. To characterize the hemodynamic changes during recovery after bicycle exercise, we used radionuclide ventriculography under the Swan-Ganz catheter insertion in 16 normal subjects and 15 patients with coronary artery disease (CAD) at rest, during bicycle exercise and after exercise periods. In normal subjects, the ejection fraction increased from resting value during peak exercise, and showed overshoot elevation in the early recovery period. In patients with CAD, the ejection fraction decreased from resting value during peak exercise, then showed overshoot elevation in the early recovery period. In normal subjects, the end-diastolic volume (EDV) and the end-systolic volume (ESV) decreased from resting value during OS. In patients with CAD, the EDV at OS was not different from that at rest, the ESV decreased from resting value during OS. The systemic vascular resistance increased from resting value during OS. The systolic blood pressure/ESV, index for ventricular contractility, increased from resting value during OS in both groups. Thus, the decreased systemic vascular resistance does not playing a major role during recovery after exercise, whereas enhanced contractility is evident in both normal subjects and patients with CAD. |
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| Practice | Clinical medicine |
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| Keywords | Exercise radionuclide ventriculography, Left ventricular ejection fraction, Overshoot, Coronary artery disease. |
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