| Japanese |
|---|
| Title | 99mTc-HMPAOと133Xe-rCBF SPECTの乖離に関する検討 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 駒谷昭夫*, 安久津徹*, 小野寺裕也*, 山口昂一* |
|---|
| Authors(kana) | |
|---|
| Organization | *山形大学医学部放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 32 |
|---|
| Number | 9 |
|---|
| Page | 989-996 |
|---|
| Year/Month | 1995/9 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」133Xeによる脳血流SPECT画像で局所的な脳血流低下があり, ほぼ同時期に99mTc-HMPAOによるSPECTが施行された30例(急性・亜急性期の脳血管障害を除く)について, 低血流域描出の乖離, およびX線CT所見との対比を行った. 99mTc-HMPAO SPECTが133Xe-rCBF SPECTと同程度の血流低下域として描出されたのは6例(20%), 133Xeより軽微なもの11例(37%), 血流低下を指摘できなかったもの13例(43%)であった. 99mTc-HMPAOで血流低下を指摘できなかった群の低下域血流は24〜35ml/100g/minであった. 99mTc-HMPAOの取り込み低下の程度は, 血流値とは相関せず, X線CT上の異常所見の程度とよく対応した. 99mTc-HMPAOの取り込み低下には, 血流値より摂取や停滞が損なわれる脳組織の損傷が直接的に関与すると考えられた. 損傷が起こる血流量には細胞毎の閾値があり, かつポアッソン分布となるためHMPAOの取り込み低下は, 血流低下に対しS字状曲線(sigmoid curve)になると解釈された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 99mTc-HMPAO, 133Xe, Regional cerebral blood flow, Single photon emission CT. |
|---|
| English |
|---|
| Title | Investigation of Discrepancy between 99mTc-HMPAO and 133Xe rCBF SPECT ; A Comparative Study with X-ray CT Findings |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Akio KOMATANI, Tohru AKUTSU, Yuuya ONODERA, Koichi YAMAGUCHI |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Radiology, Yamagata University School of Medicine |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 32 |
|---|
| Number | 9 |
|---|
| Page | 989-996 |
|---|
| Year/Month | 1995/9 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | To investigate the discrepancy between 99mTc-hexamethylpropyleneamine oxime (HMPAO) and 133Xe rCBF SPECT, the findings of thirty patients with reasonable rCBF reduction on 133Xe SPECT were compared with HMPAO SPECT and X-ray CT. The subjects did not include the cases of acute and subacute CVD. Both SPECT were performed within two weeks by ring-type dynamic SPECT (HEADTOME, Simadzu, Japan). In comparison between the SPECT findings by 133Xe and 99mTc-HMPAO, the subjects were classified into three groups as follow. Group A : Similar findings in the both SPECT were noted in 6 cases (20%). Group B : Smaller findings on HMPAO SPECT than that by 133Xe were in 11 cases (37%). Group C : No findings of rCBF reduction on HMPAO SPECT were in 13 cases (43%). The rCBF of the lesion measured by 133Xe SPECT in the group C was 24-35ml/100g/min. The density of HMPAO in the lesion did not correlate with the rCBF value. Only the severity of CT findings tend to correlate with the density of HMPAO. These results suggest that the reduction of HMPAO density depends directly on some kind of neural injury rather than the rCBF value. The injury may be caused by the flow reduction under the threshold of each neural cell. So the correlation between HMPAO density and actual rCBF might show like sigmoid curve. Then the HMPAO SPECT might directly reflect the regional extraction and fixation ratio, and the reduction of blood flow cause the minute neuralinjury in the lesion of moderately reduced rCBF. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 99mTc-HMPAO, 133Xe, Regional cerebral blood flow, Single photon emission CT. |
|---|