| Japanese |
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| Title | Elマウスのてんかん発作時局所脳血流と糖代謝 |
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| Subtitle | 原著 |
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| Authors | 細川知紗*, 越智宏暢**, 山上榮***, 河辺譲治*, 小橋肇子*, 岡村光英**, 山田龍作* |
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| Organization | *大阪市立大学医学部放射線医学教室, **核医学研究室, ***神経精神科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 9 |
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| Page | 979-987 |
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| Year/Month | 1995/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」自然発症癲癇マウスであるElマウスの発作間歇期および発作期の局所脳血流・糖代謝を, 125I-IMP, 14C-DGを用いてオートラジオグラフィで検討した. 対象は, Elマウスで, 放り上げ刺激を加え全般性強直間代発作を生じるようになったEl(+)群と, 全く刺激を誘発せず発作歴のないEl(-)群に分け, 対照群としては母系であるddYマウスを用いた. 各群マウスに125I-IMP, 14C-DGを腹腔内投与し得られた脳オートラジオグラムから, 脳局所のuptake ratioを算出した. El(+)発作間歇期には, ddY, El(-)と比較し局所脳血流は同様の分布パターンを示し, 糖代謝は海馬で高値であったが, 全脳分布パターンとしてはflowとmetabolismはcouplingした. 発作期には, 間歇期と比較し血流では有意な変化は認めなかったが, 糖代謝は海馬・扁桃核で亢進し, その他の部位では抑制され, flow-metabolism uncouplingを呈した. 発作により局所間の脳血流に明らかな差は認められず, 焦点は相対的に発作時糖代謝でのみ検出された. この血流・代謝動態は今までの癲癇の臨床および実験的研究において報告されていないパターンであり, Elマウスの二次性全般化発作の一つの成因を解明する可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | El mice, Epilepsy, Interictal phase, During seizure, Flow-metabolism uncoupling. |
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| English |
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| Title | Local Cerebral Blood Flow and Glucose Metabolism During Seizure in Spontaneously Epileptic El Mice |
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| Subtitle | Original Articles |
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| Authors | Chisa HOSOKAWA*, Hironobu OCHI**, Sakae YAMAGAMI***, Joji KAWABE*, Toshiko KOBASHI*, Terue OKAMURA**, Ryusaku YAMADA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Osaka City University Medical School, **Division of Nuclear Medicine, Osaka City University Medical School, ***Department of Psychoneurology, Osaka City University Medical Shool |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 9 |
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| Page | 979-987 |
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| Year/Month | 1995/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Local cerebral blood flow and glucose metabolism were examined in spontaneously epileptic El mice using autoradiography with 125I-IMP and 14C-DG in the interictal phase and during seizure. El(+) mice that developed generalized tonic-clonic convulsions and El(-) mice that received no stimulation and had no history of epileptic seizures were examined. The seizure non-susceptible, maternal strain ddY mice were used as control. Uptake ratios for IMP and DG in mouse brain were calculated using the autoradiographic density. In the interictal phase, the pattern of local cerebral blood flow of El(+) mice was similar to that of ddY and El(-) mice, and glucose metabolism in the hippocampus was higher in El(+) mice than in El(-) and ddY mice, but flow and metabolism were nearly matched. During seizure, no significant changed blood flow and increased glucose metabolism in the hippocampus, the epileptic focus, and no markedly changed blood flow and depressed glucose metabolism in other brain regions were observed and considered to be flow-metabolism uncoupling. These observations have never been reported in clinical or experimental studies of epilepsy. Seizures did not cause large regional differences in cerebral blood flow. Therefore, only glucose metabolism is useful for detection of the focus of secondary generalized seizures in El mice, and appeared possibly to be related to the pathophysiology of secondary generalized epilepsy in El mice. |
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| Practice | Clinical medicine |
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| Keywords | El mice, Epilepsy, Interictal phase, During seizure, Flow-metabolism uncoupling. |
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