| Japanese |
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| Title | 99mTc-HMPAO SPECTによる正常平均脳血流像の作成 - 解剖学的標準化による評価 - |
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| Subtitle | 原著 |
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| Authors | 小山真道*, 川島隆太*, 伊藤浩*, 小野修一*, 佐藤和則*, 後藤了以*, 赤井澤隆*, 吉岡清郎*, 佐藤多智雄*, 福田寛* |
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| Authors(kana) | |
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| Organization | *東北大学加齢医学研究所機能画像医学研究分野 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 9 |
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| Page | 969-977 |
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| Year/Month | 1995/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-HMPAO脳血流SPECTの正常分布パターンを知るため, 正常人における平均画像を作成し, その正常脳内RI分布パターンをvoxel by voxelで解析した. 健常人18例を対象に, 99mTc-HMPAOによる脳血流SPECTを施行した. 同日に撮像したX線CTとコンピュータ化脳図譜システム(Rolandら)を利用して, 各人のSPECT像を標準空間上の標準脳の形に移動変形した(解剖学的標準化). これらの解剖学的標準化画像から平均像および標準偏差像を作成した. 脳内RI濃度は全脳平均カウントにより補正した. 脳血流平均値像をみると, 基底核領域, 小脳, 前頭葉で高集積値を示した. また, 大脳皮質域の標準偏差が高値を示した. 99mTc-HMPAO脳血流SPECTの解剖学的標準化像は, 各種の神経精神疾患群や個々の症例における脳血流分布異常の客観的評価に応用可能であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-HMPAO, SPECT, Anatomical standardization, Cerebral blood flow(CBF), Voxel by voxel. |
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| English |
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| Title | Normal Cerebral Perfusion of 99mTc-HMPAO Brain SPECT - Evaluation by an Anatomical Standardization Technique - |
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| Subtitle | Original Articles |
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| Authors | Masamichi KOYAMA, Ryuta KAWASHIMA, Hiroshi ITO, Shuichi ONO, Kazunori SATO, Ryoui GOTO, Takashi AKAIZAWA, Seiro YOSHIOKA, Tachio SATO, Hiroshi FUKUDA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine and Radiology, Institute of Development, Aging & Cancer, Tohoku University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 9 |
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| Page | 969-977 |
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| Year/Month | 1995/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Single photon labeled tracer 99mTc-hexamethylpropylene amine oxime (HMPAO) has been used for rCBF studies by SPECT. However, normal perfusion pattern of this agent still remains unclear. The purpose of this study was to investigate normal 99mTc-HMPAO SPECT image voxel by voxel. Eighteen male subjects without any prior or present history of medical illness participated in this study. All SPECT images were globally normalized to 100 count/voxel. Each subject had an X-ray CT scan at the same day of SPECT measurement. All subjects had normal X-ray CT scans. The standard anatomical structures of the computerized brain atlas of Roland et al. were fitted to X-ray CT images of a subject by linear and non-linear parameters. These parameters were subsequently used to transform SPECT images of the subject. After the anatomical standardization, mean and SD images of eight standardized images were calculated voxel-by-voxel basis. In the mean image, following structures showed relatively higher radioactivity; the putamen, the cerebellum, and the frontal lobe. In addition, the occipital lobe, parietal lobe, frontal lobe, and the putamen showed large degree of SD. Anatomical standardization of SPECT images may be useful as a reference to diagnose and evaluate various brain disorders. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-HMPAO, SPECT, Anatomical standardization, Cerebral blood flow(CBF), Voxel by voxel. |
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