Japanese
Title左室圧過剰負荷を呈する心疾患の123I-MIBG心筋シンチグラフィの特徴 - MIBG初期心筋摂取率の高値所見について -
Subtitle原著
Authors小林秀樹*, 百瀬満**, 仁木清美**, 山住令子**, 井口信雄**, 井上征治**, 堀江俊伸**, 日下部きよ子*, 細田瑳一**
Authors(kana)
Organization*東京女子医科大学放射線科, **循環器内科
Journal核医学
Volume32
Number6
Page587-592
Year/Month1995/6
Article原著
Publisher日本核医学会
Abstract「要旨」左室圧過剰負荷を呈する大動脈弁狭窄症10例(AS群), 閉塞性肥大型心筋症11例(HOCM群), 左室圧過剰負荷がない非閉塞性肥大型心筋症17例(HCM群)および対照群6例(C群)を対象に, MIBG心筋シンチグラフィの定量的指標を検討した. MIBG初期心筋摂取率(MU)は, C群1.50±0.23%に比べ, AS群1.92±0.46%, HOCM群2.27±0.47%が有意に高値(p<0.05)であった. しかし, HCM群1.61±0.29%と, C群の間に差はなかった. MIBG心筋クリアランスは, AS群39±11%, HOCM群37±19%, HCM群28±17%とC群14±6%に比べいずれも高値(p<0.05)であった. 4時間後像の心筋縦隔比は, AS群1.87±0.29およびHCM群1.98±0.26がC群2.20±0.10に比べ低値であったが, HOCM群2.09±0.19とC群の間に差はなかった. AS群の症例においては, 左室〜大動脈平均圧格差とMUの間に正相関(r=0.618, p<0.05)が認められた. 以上より, 左室圧過剰負荷を呈するAS, HOCMでは, MUの高値がMIBG心筋シンチグラフィの特徴であった.
Practice臨床医学:一般
Keywords123I-metaiodobenzylguanidine(MIBG), Initial myocardial uptake, Aortic valve stenosis, Hypertrophic obstructive cardiomyopathy, Pressure overload state.
English
TitleThe Characteristics of 123I-MIBG Myocardial Scintigraphy in Patients with Left Ventricular Pressure-Overload Diseases
SubtitleOriginal Articles
AuthorsHideki KOBAYASHI*, Mitsuru MOMOSE**, Kiyomi NIKI**, Reiko YAMAZUMI**, Nobuo IGUCHI**, Seiji INOUE**, Toshinobu HORIE**, Kiyoko KUSAKABE*, Saichi HOSODA**
Authors(kana)
Organization*Department of Radiology, **Department of Cardiology, Tokyo Women's Medical College Hospital
JournalThe Japanese Journal of nuclear medicine
Volume32
Number6
Page587-592
Year/Month1995/6
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractThe purpose of this study was to clarify the clinical significance of 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in patients with left ventricular pressure-overload diseases. MIBG scintigraphy was applied to 10 pts with aortic valve stenosis (AS group), 11 pts with hypertrophic obstructive cardiomyopathy (HOCM group), 17 pts with hypertrophic non-obstructive cardiomyopathy (HCM group) and 6 control cases (C group). Mean pressure gradient in AS and HOCM groups was 62+-21 mmHg and 38+-18 mmHg, respectively. Initial myocardial uptake of MIBG (MU) was higher in the AS (1.92+-0.46%) and HOCM (2.27+-0.47%) groups than those in the HCM (1.61+-0.29%) and C (1.50+-0.23) groups. Myocardial clearance of MIBG (MC) was higher in the AS (39+-11%), HOCM(37+-19%) and HCM (28+-17%) groups than that in the C (14+-6%) groups. Heart/mediastinum count ratio (H/M) of AS, HOCM, HCM and C groups was 1.87+-0.29, 2.09+-0.19, 1.98+-0.26, and 2.20+-0.10, respectively. In the cases of AS, positive correlation was observed between mean pressure gradient and MU (r=0.618, p<0.05). In conclusion, MU was increased in the case of left ventricular pressure-overload state (AS and HOCM).
PracticeClinical medicine
Keywords123I-metaiodobenzylguanidine(MIBG), Initial myocardial uptake, Aortic valve stenosis, Hypertrophic obstructive cardiomyopathy, Pressure overload state.

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