| Japanese |
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| Title | 全身スキャンによる123I-BMIPP心筋集積率について : 血中エネルギー基質濃度が及ぼす影響についての検討 |
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| Subtitle | 原著 |
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| Authors | 土持進作*, 玉木長良*, 河本雅秀*, 多田村栄二*, 藤田透*, 野原隆司**, 松森昭**, 篠山重威**, 米倉義晴***, 小西淳二* |
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| Authors(kana) | |
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| Organization | *京都大学医学部核医学科, **第三内科, ***脳病態生理学 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 6 |
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| Page | 579-586 |
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| Year/Month | 1995/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」血中エネルギー基質濃度がBMIPP心筋集積率に及ぼす影響について検討した. 対象は26例の心疾患患者で, いずれも前日夕食摂取後からの絶食状態下で静脈血採血を行い, 同時に123I-BMIPP 111MBqを静注し, 1時間後に全身前後像を撮像した. これから心筋集積率(% uptake)を算出し, 前面像からは心縦隔比(H/M)を求めた. % uptakeの平均は3.70±1.22%, H/Mは2.30±0.23で, DCM群は他群に比べ有意に% uptakeが高値を示した(5.58±0.67%)が, H/Mについては有意差は認められなかった. B.S., NEFA, insulinのいずれも% uptake, H/Mとの間に明らかな相関関係は認められなかった. % uptakeとH/Mの間にはr=0.80の正の相関(p<0.001)が認められた. 通常の絶食条件下では心筋へのBMIPP集積は血中エネルギー基質濃度に影響されないと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-beta-methyl iodophenylpentadecanoic acid(123I-BMIPP), Myocardial uptake, Biochemical data. |
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| English |
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| Title | Myocardial Uptake Ratio of Iodine-123 Labeled Beta-Methyl Iodophenylpentadecanoic Acid (123I-BMIPP) in Relation to the Concentration of the Substrates of Energy |
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| Subtitle | Original Articles |
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| Authors | Shinsaku TSUCHIMOCHI*, Nagara TAMAKI*, Masahide KAWAMOTO*, Eiji TADAMURA*, Toru FUJITA*, Ryuji NOHARA**, Akira MATSUMORI**, Shigetake SASAYAMA**, Yoshiharu YONEKURA***, Junji KONISHI* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Third Division, Department of Internal Medicine, ***Department of Brain Pathophysiology, Kyoto University Faculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 6 |
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| Page | 579-586 |
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| Year/Month | 1995/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Iodine-123 beta-methyl iodophenylpentadecanoic acid (BMIPP) has been used for evaluating myocardial fatty acid metabolism in vivo. The whole body BMIPP imaging was acquired in 26 patients (11 with HCM, 11 with CAD and 4 with DCM) to calculate % uptake in the myocardium and to correlate its uptake with biochemical data, including blood sugar (BS), nonesterified fatty acid (NEFA) and insulin in the blood. BMIPP was administered at rest with overnight fasting state, and the anterior and posterior whole body imaging was performed one hour later. The background corrected whole myocardial counts were calculated to obtain %BMIPP uptake. In addition, the heart to mediastinum count ratio (H/M ratio) was calculated from the mean counts in the heart and the upper mediastinum in the anterior view. The %BMIPP uptake was 3.70+-1.22% and H/M ratio was 2.30+-0.23. The patients with DCM showed higher %BMIPP uptake values(DCM=5.58+-0.67% vs. CAD=3.09+-0.97% and HCM=3.63+-0.86%, both p<0.01), but similar values of H/M ratio with other patients (DCM=2.43+-0.20, CAD=2.22+-0.25 and HCM=2.32+-0.20). Although the biochemical data varied at the time of the tracer administration, they were not significantly correlated with the %BMIPP uptake or H/M ratio. However, there was a significant correlation between %BMIPP uptake and H/M ratio with the correlation coefficient of 0.80 (p<0.001). We conclude that the myocardial uptake of BMIPP is not influenced by the plasma substrate level under the fasting state. |
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| Practice | Clinical medicine |
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| Keywords | 123I-beta-methyl iodophenylpentadecanoic acid(123I-BMIPP), Myocardial uptake, Biochemical data. |
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