| Japanese |
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| Title | 慢性脳動脈閉塞例におけるCO2とDiamox負荷に対する脳血管反応の比較 - H2 15O PETによる検討 - |
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| Subtitle | 原著 |
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| Authors | 桑原康雄*, 一矢有一*, 佐々木雅之*, 赤司祐子*, 福村利光*, 吉田毅*, 増田康治* |
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| Authors(kana) | |
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| Organization | *九州大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 6 |
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| Page | 569-577 |
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| Year/Month | 1995/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」H2 15O PETを用い慢性脳動脈閉塞例を対象にCO2吸入時とDiamox静注後に脳血流を測定し, 脳血管反応を両者で比較検討した. 対象は一側内頸動脈閉塞5例と高度狭窄6例の計11例である. 脳血流は安静時, 5%CO2吸入開始2分, Diamox(1g)静注後5分と20分に測定した. CO2負荷時とDiamox負荷時の脳血流の患側/健側比はよく相関したが, Diamox投与20分後の方が5分後よりもCO2負荷時との相関がよかった. CO2負荷時とDiamox投与後の脳血流変化率も有意に相関したが, Diamox投与5分後では患側において脳血流が逆に減少するsteal現象が少なからずみられ, 同部での反応の遅れが示唆された. また, 個々の例でバラツキがみられるもののDiamox 1g負荷時の脳血流増加率は5%CO2吸入時の増加率よりやや多いか同等であり, PaCO2では10mmHgの上昇に相当した. したがって, CO2とDiamox負荷ではほぼ同等の情報が得られると考えられたが, 臨床検査に用いる場合にはそれぞれの特徴を考慮し負荷法を選択すべきと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | CO2 response, Diamox, H2 15O, Positron emission tomography, Occlusive cerebrovascular disease. |
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| English |
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| Title | A Comparison of the Cerebrovascular Responses to CO2 and Diamox in Patients with Unilateral Occlusive Cerebral Arteries : A H2 15O PET Study |
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| Subtitle | Original Articles |
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| Authors | Yasuo KUWABARA, Yuichi ICHIYA, Masayuki SASAKI, Yuko AKASHI, Tsuyoshi YUSHIDA, Toshimitsu FUKUMURA, Kouji MASUDA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Faculty of Medicine, Kyushu University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 6 |
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| Page | 569-577 |
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| Year/Month | 1995/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We studied the relationship between the cerebrovascular responses to CO2 and Diamox in patients with chronic cerebrovascular diseases. The subjects consisted of 11 patients with unilateral occlusive or highly stenotic carotid artery. The cerebral blood flow was measured at the resting state, during the inhalation of 5% CO2, at both 5 and 20 min after Diamox i. v. (1g). The rCBF ratios (occlusive/non-occlusive side) during the inhalation of CO2 and 20 min after Diamox i. v. closely correlated with each other. However, the ratio at 5 min after Diamox i. v. was slightly lower than that during the inhalation of CO2. The percent increases of rCBF also showed a significant correlation between 5% CO2 inhalation and 20 min after Diamox i. v. However, the rCBF decreased inversely at 5 min after Diamox i. v. in some regions on the occlusive side, which indicates the presence of a so-called "steal phenomenon". The percent increases in the rCBF after 1 g Diamox i. v. were more or equal to those during the inhalation of 5% CO2. The CO2 and Diamox were thus considered to be equally useful in the evaluation of the perfusion reserve capacity. However, these various characteristics as described above should be considered in the clinical practice. |
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| Practice | Clinical medicine |
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| Keywords | CO2 response, Diamox, H2 15O, Positron emission tomography, Occlusive cerebrovascular disease. |
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