| Japanese |
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| Title | Pertechnegasの物理化学的性状と吸入後の肺クリアランス |
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| Subtitle | 原著 |
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| Authors | 富永滋*, 島田孝夫**, 川上憲司***, 吉沢幸夫**** |
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| Authors(kana) | |
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| Organization | *順天堂大学浦安病院内科, **東京慈恵会医科大学第三内科, ***放射線科, ****アイソトープセンター |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 6 |
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| Page | 563-567 |
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| Year/Month | 1995/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Technegas generatorを使用し, 発生条件の一部を改変し3%の酸素の混合下で作成したPertechnegasの物理化学的性状を推定するとともに吸入後の肺クリアランス動態について検討した. Pertechnegasは生理食塩水によく抽出され, またネズミに静注後の体内分布やRadiochromatographyの結果もPertechnetate(99mTcO4-)とよく一致していた. 正常人でのPertechnegasの肺クリアランス半減時間(T1/2)も99mTc-O4-エロソールの場合と有意差はなかった. Pertechnegasの肺クリアランスは喫煙者では亢進し, 上肺野において下肺野より速い点などDTPAエロソールと類似しているところもあった. 今後疾患肺での動態, 臨床的有用性について検討を要する. |
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| Practice | 臨床医学：一般 |
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| Keywords | Technegas, Pertechnegas, Lung epithelial permeability, Radiochromatography. |
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| English |
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| Title | Physicochemical Characterization and Lung Clearance of Pertechnegas |
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| Subtitle | Original Articles |
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| Authors | Shigeru TOMINAGA*, Takao SHIMADA**, Kenji KAWAKAMI***, Yukio YOSHIZAWA**** |
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| Authors(kana) | |
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| Organization | *Department of Internal Medicine, Juntendo University Urayasu Hospital, **Third Department of Internal Medicine, ***Department of Radiology, ****Radioisotope Center, Jikei University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 6 |
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| Page | 563-567 |
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| Year/Month | 1995/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Pertechnegas, which is a variant of technegas, is an ultrafine carbon aerosol formed inside a technegas generator in the presence of 3% oxygen and 97% argon. The easy extractability of the pertechnegas in the phosphate buffered saline (PBS), the distribution seen in rats after intravenous injection of the pertechnegas and the results of the radiochromatography showed that the pertechnegas behaved like pertechnetate (TcO4-). In vivo study, the clearance half time (T1/2) of inhaled pertechnegas has shown no significant difference to that of TcO4- aerosol in 7 normal subjects. T1/2 of the pertechnegas was considerably faster in comparison with T1/2 of DTPA aerosol. However, T1/2 of the pertechnegas was more rapid in 6 smokers compared with T1/2 in 4 nonsmokers (p<0.01), and was also increased in the upper lung field compared with the lower lung field (p<0.01); these results closely correlate with those obtained with DTPA aerosol. Further study of the clearance of the pertechnegas in pulmonary diseases is required to assess clinical usefulness. |
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| Practice | Clinical medicine |
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| Keywords | Technegas, Pertechnegas, Lung epithelial permeability, Radiochromatography. |
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