| Japanese |
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| Title | 99mTc-methoxyisobutylisonitrileによる過機能上皮小体の局在診断 - 99mTcO4-とのサブトラクション法の検討 - |
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| Subtitle | 原著 |
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| Authors | 片桐誠*, 大多和孝博*, 大塚信昭**, 森田浩一**, 曽根照喜**, 三村浩朗**, 柳元真一**, 福永仁夫**, 原田種一* |
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| Authors(kana) | |
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| Organization | *川崎医科大学内分泌外科学教室, **核医学教室 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 5 |
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| Page | 465-472 |
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| Year/Month | 1995/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」手術が施行された上皮小体腺腫6例と慢性腎不全に伴う二次性上皮小体過形成13例の計19例を対象に99mTc-methoxyisobutylisonitrile(MIBI)と99mTcO4-を用いたサブトラクションシンチグラフィ(MIBI-Tc)を行い, 過機能上皮小体の検出能を検討し, 201Tl-Clと99mTcO4-を用いたサブトラクションシンチグラフィ(Tl-Tc)の成績と比較した. MIBI-Tcによる腺腫と過形成の検出率は, それぞれ83.3%と51.9%で, Tl-Clのそれと有意差は認められなかった. MIBI-Tcの検出率は上皮小体の最大径および重量に依存したが, 検出し得た最小の上皮小体は腺腫では最大径15mm, 重量290mgで, 過形成では最大径9mm, 重量50mgであった. また, シンチグラム上甲状腺と重なって存在した上皮小体と甲状腺と離れて存在した上皮小体との間に検出率の差は認められなかった. 99mTc-MIBIは過機能上皮小体の検出率に関しては201Tl-Clとの間に有意差は認められなかったが, 201Tl-Clより優れた物理学的特性を有しているので, 上皮小体の局在診断用の新しい放射性医薬品として期待される. |
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| Practice | 臨床医学：一般 |
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| Keywords | Parathyroid gland, 99mTc-methoxyisobutylisonitrile, 201Tl-Cl, Subtraction scintigraphy. |
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| English |
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| Title | Detection and Localization of Enlarged Parathyroid Glands in Patients with Hyperparathyroidism using 99mTc-Methoxyisobutylisonitrile (MIBI) : A Study of Subtraction Scintigraphy with 99mTc-Pertechnetate |
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| Subtitle | Original Articles |
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| Authors | Makoto KATAGIRI*, Takahiro OHTAWA*, Nobuaki OTSUKA**, Koichi MORITA**, Teruki SONE**, Hiroaki MIMURA**, Shinichi YANAGIMOTO**, Masao FUKUNAGA**, Tanekazu HARADA* |
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| Authors(kana) | |
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| Organization | *Department of Endocrine Surgery, **Department of Nuclear Medicine, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 5 |
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| Page | 465-472 |
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| Year/Month | 1995/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | In this study we investigated the detectability of abnormal parathyroid gland(s) by 99mTc-methoxyisobutylisonitrile (MIBI) scintigraphy in patients with hyperparathyroidism. The subjects were 6 patients with primary hyperparathyroidism (PHP) with a single adenoma and 13 patients with renal hyperparathyroidism (RHP) on chronic maintenance hemodialysis. The imaging data of 99mTc-pertechnetate were subtracted from those of 99mTc-MIBI (MIBI-Tc), and number and location of the positive images on scintigrams were compared with those obtained by conventional scintigraphy using 201Tl-Cl and 99mTc-pertechnetate (Tl-Tc). All of the patients underwent surgery, and the number and location of the abnormal parathyroid glands were confirmed. The number of resected parathyroid glands were 6 in PHP and 52 in RHP. The detectability of MIBI-Tc was 83.3% in PHP and 51.9% in RHP, while that of Tl-Tc was 100% and 44.2%, respectively. Although no statistically significant difference in the detectability was found between MIBI-Tc and Tl-Tc, the number of false positives with MIBI-Tc was less than that with Tl-Tc. The detectability of MIBI-Tc depended on the size of the parathyroid gland. The maximal diameter and weight of the smallest parathyroid gland detected were 15 mm and 290 mg in PHP, and 9 mm and 50 mg in RHP. The existence of the thyroid gland did not reduce the detectability of MIBI-Tc. In conclusion, MIBI-Tc was clinically very useful for the detection of abnormal parathyroid glands in patients with hyperparathyroidism. |
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| Practice | Clinical medicine |
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| Keywords | Parathyroid gland, 99mTc-methoxyisobutylisonitrile, 201Tl-Cl, Subtraction scintigraphy. |
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