| Japanese |
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| Title | 99mTc-GSAを用いたラット肝血行遮断モデルにおける肝血流量の評価 |
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| Subtitle | 原著 |
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| Authors | 平口悦郎* |
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| Organization | *北海道大学医学部第二外科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 5 |
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| Page | 453-463 |
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| Year/Month | 1995/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肝血行遮断が99mTc-GSAの肝集積に及ぼす影響を明らかにする目的で, 正常肝ラットおよび四塩化炭素投与による慢性肝障害ラットを用いて, それぞれ単開腹(LAP), 肝動脈結紮(HAL), 門脈結紮(PVL), 両者結紮(HAL+PVL)の4つの肝血行遮断モデルを作成し, 99mTc-GSAの血中消失をあらわすパラメータ(HH4, Kd)および肝集積をあらわすパラメータ(LHL4, Ku)を測定した. 正常肝群でも, 肝障害群においても, それぞれHH4の値はLAPに対してHAL, PVL, HAL+PVLの順に上昇し, LHL4, KdおよびKuの値はHAL, PVL, HAL+PVLの順に低下した. レーザードップラー血流計によって測定した肝組織血流変化率とHH4, LHL4, KdおよびKuの間には有意な高い相関が認められた. 以上の結果より99mTc-GSAパラメータは正常肝においても慢性肝障害においても血行遮断による肝血流量の変化と有意に相関することが示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-DTPA-galactosyl human serum albumin(99mTc-GSA), CCl4 induced chronic liver injury, Hepatic tissue blood flow, Hepatic artery ligation, Portal vein ligation. |
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| English |
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| Title | Evaluation of Hepatic Blood Flow Using 99mTc-GSA in Rats with Hepatic Blood Flow Manipulation |
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| Subtitle | Original Articles |
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| Authors | Etsuo HIRAGUCHI |
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| Authors(kana) | |
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| Organization | Second Department of Surgery, Hokkaido University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 5 |
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| Page | 453-463 |
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| Year/Month | 1995/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Blood clearance and hepatic uptake parameters of 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) were evaluated in two groups of rats, normal liver group and CCl4 induced chronic liver injury group. In each group, four subgroups were classified as follows: simple laparotomy (LAP), hepatic artery ligation (HAL), portal vein ligation (PVL) and both hepatic artery and portal vein ligation (HAL+PVL). 99mTc-GSA was intravenously injected (50μg/100g B. W. ) to rats. Heart and liver were targetted as region of interest and time activity curves (TACs) were obtained. The blood clearance parameters (HH4 and Kd) and the hepatic uptake parameters (LHL4 and Ku) were calculated from these TACs. In normal liver group, the mean HH4 of LAP was significantly different from those of PVL and HAL+PVL. Similarly, the other three parameters (LHL4, Kd and Ku) of LAP were significantly different from those of PVL and HAL+PVL. CCl4 induced chronic liver injury group showed significant difference on all four parameters in four subgroups. Hepatic tissue blood flow rates (HTBFR) calculated by Laser Doppler flowmeter correlated well with 99mTc-GSA parameters in both groups. These results suggest that 99mTc-GSA is useful to estimate hepatic blood flow not only in rats with normal liver, but also in rats with CCl4 induced chronic liver injury. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-DTPA-galactosyl human serum albumin(99mTc-GSA), CCl4 induced chronic liver injury, Hepatic tissue blood flow, Hepatic artery ligation, Portal vein ligation. |
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