| Japanese |
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| Title | 肝腫瘍切除術前後における99mTc-GSA肝機能指標の変動 |
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| Subtitle | 技術報告 |
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| Authors | 野口敦司*, 長谷川義尚*, 佐々木洋**, 今岡真義**, 橋詰輝己*, 井深啓次郎*, 若杉茂俊*, 中野俊一* |
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| Organization | *大阪府立成人病センター核医学診療科, **外科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 4 |
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| Page | 419-426 |
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| Year/Month | 1995/4 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肝腫瘍14例において肝腫瘍切除術前後に99mTc-GSAシンチグラフィを施行し, 肝容積および肝機能諸指標の変化を計測した. 肝容積は全例で肝切除術後に減少した (p<0.001). 一方, 肝機能指標であるLU15は14例のうち7例で前値の10%以上増加し, HH15は2例で前値の10%以上減少した. また, 肝集積計数値 (SPECT) は14例のうち6例で前値の10%以上増加し, 10%以上減少したものは1例であった. さらに, 左右肝葉別に容積および肝集積計数値を測定し, 術後に肝全体で肝細胞再生が生じていることを示唆する成績を得た. 以上, 肝切除術前後に99mTc-GSAシンチグラフィを施行し, 肝容積が減少したにもかかわらず, 99mTc-GSA肝機能諸指標において, 改善を示す例が少なくないことを明らかにした. また, 術後の機能肝細胞の再生が肝全体に生じていることが, この現象の大きな原因と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-GSA, Hepatic tumors, Liver volume, Hepatectomy, Liver regeneration |
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| English |
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| Title | Changes of Liver Function Measured by 99mTc-GSA Scintigraphy after Hepatectomy |
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| Subtitle | |
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| Authors | Atsushi NOGUCHI*, Yoshihisa HASEGAWA*, Yoh Sasaki**, Shingi IMAOKA**, Terumi HASHIZUME*, Keijirou IBUKA*, Shigetoshi WAKASUGI*, Shunichi NAKANO* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Surgery, The Center for Adult Diseases |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 4 |
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| Page | 419-426 |
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| Year/Month | 1995/4 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In 14 patients with hepatic tumors, liver volume and liver function indices were studied by 99mTc-GSA liver scintigraphy before and after hepatectomy. The liver volume measured by 99mTc-GSA SPECT was significantly decreased after surgery in all 14 patients (p<0.001). Postsurgically, 7 patients showed an increase of greater than 10% in the LU15 value, while 3 showed a decrease of 10%. Two patients showed a decrease of greater than 10% in the HH15 value after surgery. The changes in LU15 after surgery were inversely correlated with those in HH15. The present findings clarified that in several cases of surgically treated hepatic tumors, 99mTc-GSA indices of liver function generally thought to indicate the size of the functioning liver cell mass were distinctly improved after surgery in comparison with those before surgery, despite the postoperative decrease in the liver volume. Furthermore, the results of a 99mTc-GSA SPECT study separately measuring the volume of the unilateral hepatic lobe and its radioactivity uptake, indicated that regeneration of the functioning liver cells often occurred in the entire liver. 99mTc-GSA scintigraphy appears to be a valuable method for evaluating changes in both the liver volume and the liver function indices after hepatectomy. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-GSA, Hepatic tumors, Liver volume, Hepatectomy, Liver regeneration |
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