| Japanese |
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| Title | N-isopropyl-p-[123I]iodoamphetamineとSPECTを用いたARG法による局所脳血流定量法の検討 - テーブル・ルック・アップ (TLU) 法との比較および静脈採血法の問題点 - |
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| Subtitle | 原著 |
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| Authors | 齋藤京子*, 村田啓**, 丸野広大**, 奥田逸子** |
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| Organization | *虎の門病院放射線部, **放射線科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 4 |
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| Page | 405-412 |
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| Year/Month | 1995/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」動脈1回採血と123I-IMP SPECT 2回スキャンによるTLU法およびSPECT 1回スキャンによるARG法による局所脳血流量 (rCBF) 値について比較検討した. 今回検討した17症例ではpost ischemic hyperperfusionやluxury perfusionを認めなかった. TLU法から求めた分布容積 (Vd値) とrCBF値の相関係数は早期像にて低集積域を除く184の関心領域において0.49, 低集積域をも含めた207の関心領域の場合は0.61でありいずれも有意の正の相関 (p<0.001) を示した. またVd値が低くrCBF値が高い部位は認められなかった. Vd値を一定値に設定することがrCBF値に大きな誤差を与えやすい部位はrCBF値の高い部位であった. 全領域におけるVdの平均値は44.0±7.0であった. Vd値を44および50に設定したARG法とTLU法のrCBF値の相関は相関係数が0.98ときわめて良好であり, ARG法によりrCBFの定量を簡便化し得る. 123I-IMP静注後10分における静脈血のカウントは動脈血よりも低く, 採血部位により異なり末梢部ほど動脈血カウントに近かった. 手背部からの静脈血カウント/動脈血カウントは0.92±0.04 (n=10) であった. 手背部からの静脈血カウントを0.92で除することにより動脈血から得られるrCBF値により近いrCBF値が得られたが, 安定した誤差の少ないrCBF値を得るためには動脈採血が望ましいと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, SPECT, Regional cerebral blood flow, Look-up table method, Autoradiography method |
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| English |
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| Title | A Study of rCBF Measurement with Autoradiography (ARG) Method Using N-Isopropyl-p-[123I]Iodoamphetamine (IMP) and SPECT - Comparison of rCBF Values between Look-up Table (TLU) and ARG Methods, and Evaluation of Venous Blood Sampling as a Substitute for Arterial Blood Sampling - |
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| Subtitle | |
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| Authors | Kyoko SAITO, Hajime MURATA, Hirotaka MARUNO, Itsuko OKUDA |
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| Organization | Division of Nuclear Medicine, Toranomon Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 4 |
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| Page | 405-412 |
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| Year/Month | 1995/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Regional cerebral blood flow (rCBF) values obtained by the TLU method with two 123I-IMP SPECT scans and one point arterial blood sampling and rCBF obtained by the ARG method with one 123I-IMP SPECT scan and fixed distribution volume (Vd) values were compared in 17 cases. A case with post ischemic hyperperfusion or luxury perfusion was not observed in our cases. The correlation coefficients between rCBF values and Vd values obtained by the TLU method were 0.49 (p<0.001) in 184 ROI without hypoactive areas on the early image, and 0.61 (p<0.001) in 207 ROI with hypoactive areas, respectively. A high rCBF value with a low Vd value was not observed in any region. Mean Vd value was 44.0+-7.0 (mean+-SD) in all regions. The correlation coefficients between rCBF values using the TLU method and those using the ARG method with Vd fixed at 44 and 50 were also 0.98. Error of the rCBF value was larger in the region of high rCBF, however, noticeable error of the rCBF value was not observed in the ARG method. The ARG method is more convenient for quantifying rCBF. Venous blood radioactivity at 10 min after 123I-IMP infusion was smaller than arterial blood radioactivity, and the blood activity in the distal vein was larger than that in the proximal vein. The ratio of venous blood activity to arterial blood activity was 0.92+-0.04 (mean+-SD) at the back of the hand, however, the ratio was a variant in each case. Arterial sampling was thought to be a reliable method to obtain more stable and precise rCBF. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, SPECT, Regional cerebral blood flow, Look-up table method, Autoradiography method |
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