| Japanese |
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| Title | 肥大型心筋症における123I-BMIPP集積低下部位の特徴 - 非対称性中隔肥大を伴う肥大型心筋症に関する検討 - |
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| Subtitle | 原著 |
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| Authors | 大槻克一*, 杉原洋樹**, 伊藤一貴*, 松本雄賀*, 谷口洋子*, 寺田幸治*, 中川達哉*, 島孝友*, 栗林敏郎*, 落合正和***, 前田知穂**, 中川雅夫* |
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| Authors(kana) | |
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| Organization | *京都府立医科大学第二内科, **放射線科, ***京都府立洛東病院循環器科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 4 |
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| Page | 377-385 |
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| Year/Month | 1995/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肥大型心筋症 (HCM) における123I-BMIPPの集積低下部位の特徴を検討した. 非対称性中隔肥大 (ASH) を伴うHCM連続26症例を対象とし, 123I-BMIPP静注15分後にSPECT像を撮像した. SPECT短軸像, 垂直長軸像を合計17領域に分割し, 各領域毎にトレーサの集積低下の程度を5段階評価 (Defect Score (DS)) した. 123I-BMIPP集積低下 (DS≧2) の頻度は, 前壁のうち中隔よりの領域 (65%), 後壁のうち中隔よりの領域 (62%), 心尖部 (73%) において高頻度であった. 123I-BMIPP集積低下の程度は, 中隔に比し前壁のうち中隔よりの領域 (p<0.001), 後壁のうち中隔よりの領域 (p<0.01), 心尖部 (p<0.01) において高度であった. ASHを伴うHCMでは前壁, 後壁のうち心室中隔よりの領域と心尖部で心筋脂肪酸代謝障害が最も高度であることが示唆された. また, HCM剖検例の病理組織学的所見に関する報告をあわせ考えると心筋脂肪酸代謝障害と心筋構築異常との関連が推察された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Hypertrophic cardiomyopathy, 123I-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), Fatty acid metabolism |
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| English |
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| Title | The Characteristic Feature of Myocardial Imaging with 123I-Labeled 15-(p-Iodophenyl)-3R,S-Methylpentadecanoic Acid in Hypertrophic Cardiomyopathy with Asymmetric Septal Hypertrophy |
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| Subtitle | Original Articles |
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| Authors | Katsuichi OHTSUKI*, Hiroki SUGIHARA**, Kazuki ITO*, Katsushige MATSUMOTO*, Yoko TANIGUCHI*, Kouji TERADA*, Tatsuya NAKAGAWA*, Takatomo SHIMA*, Toshirou KURIBAYASHI*, Masakazu OCHIAI***, Tomoho MAEDA**, Masao NAKAGAWA* |
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| Authors(kana) | |
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| Organization | *Second Department of Medicine, **Department of Radiology, Kyoto Prefectural University of Medicine, ***Department of Cardiology, Kyoto Prefectural Rakuto Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 4 |
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| Page | 377-385 |
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| Year/Month | 1995/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The aim of this study was to elucidate the characteristic feature of myocardial imaging with 123I-labeled 15-(p-iodophenyl)-3R,S-methylpentadecanoic acid (BMIPP) in the patients with hypertrophic cardiomyopathy (HCM). In 26 patients with asymmetric septal hypertrophy (ASH), the imaging data were acquired for 15 minutes after the injection of 123I-BMIPP by the emission computed tomography (ECT). ECT image was divided into 17 segments to score the severity of the defect in each segment using a 5-point grading system from score 3 to score -1 ; score 3=severely decreased tracer uptake, score 2=moderately decreased tracer uptake, score 1=mildly decreased tracer uptake, score 0=normal and score -1=increased tracer uptake. Reduced uptake (Defect Score >=2) was frequently observed in septal portion of anterior wall (65%), septal portion of posterior wall (62%) and apical wall (73%). Defect score was higher in septal portion of anterior wall (p<0.001), septal portion of posterior wall (p<0.01) and apical wall (p<0.01) than in the ventricular septum. This result indicates that in hearts with ASH, 123I-BMIPP image reveals severely impaired fatty acid metabolism in these regions. With the reference of the previous report about histologic features in necropsy hearts with HCM, myocardial fatty acid metabolic disorder shown by reduced 123I-BMIPP uptake is closely related to the histological abnormalities in hearts with HCM. |
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| Practice | Clinical medicine |
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| Keywords | Hypertrophic cardiomyopathy, 123I-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), Fatty acid metabolism |
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