| Japanese |
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| Title | 虚血性心疾患における安静時123I-BMIPP心筋シンチグラフィの意義 : 201Tl-運動負荷心筋シンチグラフィとの比較検討 |
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| Subtitle | 原著 |
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| Authors | 滝淳一*, 中嶋憲一*, 松成一朗*, 分校久志**, 高田重男***, 村守朗*, 利波紀久*, 久田欣一* |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学科, **医療情報部, ***第一内科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 4 |
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| Page | 353-358 |
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| Year/Month | 1995/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患を対象として安静時123I-BMIPP像と運動負荷201Tl心筋シンチグラフィならびに左室造影による壁運動障害の程度を比較検討した. 虚血性心疾患31例を対象とし1週間以内に, 安静時123I-BMIPP SPECTと運動負荷-再静注201Tl SPECTを施行した. 201Tlシンチグラフィで虚血と判定された159領域ではBMIPPと再静注201Tlの集積を比較すると, 64区域では両者が同等であり, 76区域ではBMIPPの集積がより低下し, 19区域では逆であった. 一方201Tlシンチグラフィで再分布のない集積低下部53区域では, 41区域でBMIPPと再静注201Tlの集積は同等であり3区域でBMIPPがより低下し, 9区域では201Tlがより低下していた (p<0.001). 虚血領域でBMIPPの集積低下が201Tl再静注時集積低下より強い領域とそうでない領域で壁運動を比較すると, BMIPPの集積低下の強い部位では54区域中32区域 (59%) で壁運動が高度に低下していたが, BMIPPの集積低下が201Tlのそれと同等か軽度である場合は75区域中21区域 (28%) で高度に低下しているに過ぎなかった (p<0.005). 以上より虚血領域では安静時BMIPPの集積は安静時血流に近いと考えられる再静注201Tlより有意に集積が低い場合が多く, かつそのような領域では壁運動障害が高度であり, BMIPPを用いることにより心筋障害の程度をより詳細に検討できると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 201Tl, 123I-BMIPP, Coronary artery disease, Fatty acid metabolism |
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| English |
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| Title | Value of 123I-BMIPP Scintigraphy in Patients with Ischemic Heart Disease : Comparison with Exercise 201Tl SPECT |
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| Subtitle | Original Articles |
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| Authors | Junichi TAKI*, Kenichi NAKAJIMA*, Ichiro MATSUNARI*, Hisashi BUNKO*, Shigeo TAKADA**, Akira MURAMORI*, Norihisa TONAMI*, Kinichi HISADA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **First Department of Internal Medicine, School of Medicine Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 4 |
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| Page | 353-358 |
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| Year/Month | 1995/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To evaluate 123I labeled beta-methyl-branched fatty acid (BMIPP) myocardial uptake at rest in the segment with and without stress induced ischemia in patients with coronary artery disease, 123I-beta-methyl-branched fatty acid myocardial scintigraphy was performed at rest and was compared with the findings of stress-reinjection 201Tl myocardial scintigraphy in 31 patients with coronary artery disease. In 159 ischemic myocardial segments, equally decreased uptake on both reinjection 201Tl and fatty acid images was observed in 64 segments, more severely decreased uptake of fatty acid in 76 segments, and more severely decreased uptake of reinjection thallium in 19 segments. On the other hand, in 53 non-reversible defects, each patterns was observed in 41, 3, and 9 segments respectively. When comparing the ischemic segments with more reduced uptake of fatty acid than reinjection thallium (Group 1) and the ischemic segments with equally or less reduced fatty acid uptake than reinjection thallium (Group 2), wall motion was more severely impaired in Group 1 than in Group 2 (severe hypo- to dyskinesis was present in 32 of 54 segments in group 1 and in 21 of 75 segments in group 2, p<0.005). In conclusion, in patients with coronary artery disease, resting fatty acid uptake was frequently more reduced than reinjection 201Tl in the segments with stress induced ischemia and wall motion was more impaired in these segments. BMIPP myocardial imaging may provide information on metabolic alterations at rest independent of perfusion abnormalities in patients with coronary artery disease. |
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| Practice | Clinical medicine |
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| Keywords | 201Tl, 123I-BMIPP, Coronary artery disease, Fatty acid metabolism |
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