| Japanese |
|---|
| Title | 123I-IMPを用いたSPECT 1回スキャンと1回採血による局所脳血流量の測定 - 統計的誤差要因の解析と最適なSPECTスキャン中心時刻に関する検討 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 飯田秀博*, 中澤真弓**, 上村和夫*** |
|---|
| Authors(kana) | |
|---|
| Organization | *秋田県立脳血管研究センター放射線医学研究部, **日本メジフィジックス株式会社学術部, ***秋田県立脳血管研究センター所長 |
|---|
| Journal | 核医学 |
|---|
| Volume | 32 |
|---|
| Number | 3 |
|---|
| Page | 263-270 |
|---|
| Year/Month | 1995/3 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」近年, 123I-IMP静注後1回のSPECTスキャンと1回の動脈採血手順により局所脳血流量を定量する方法であるIMP-ARG法が開発された. この方法で誤差要因になると考えられる三つの要素, すなわち, 設定した分布容積 (distribution volume, Vd) 値, 入力関数の個人差およびSPECT精度につき, 発生する誤差をシミュレーションにより検討し, 最適なスキャン時刻を評価した. Vd値の誤差の影響は高血流量域で比較的大きく, また, スキャン中心時刻が遅いほど大であった. 入力関数の個人差の影響は, スキャン中心時刻が遅い時も早い時も大きくなった. 本研究により, 最適なスキャン中心時刻は123I-IMP静注後30分であると考えられた. この時の局所脳血流量値の誤差はSPECT装置の精度が十分高いとすると13%程度であると見積られた. 高血流量域でのVd値の個人差および入力関数の個人差は, 今後, より大きなデータベースで検討されることが望ましい. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | N-isopropyl-p-[123I]iodoamphetamine, Single photon emission computed tomography, Regional cerebral blood flow, and quantification |
|---|
| English |
|---|
| Title | Quantitation of Regional Cerebral Blood Flow Using 123I-IMP from a Single SPECT Scan and a Single Blood Sampling - Analysis on Statistical Error Source and Optimal Scan Time - |
|---|
| Subtitle | |
|---|
| Authors | Hidehiro IIDA*, Mayumi NAKAZAWA**, Kazuo UEMURA*** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, **Nihon Medi-Physics, ***Akita Research Institute of Brain and Blood Vessels |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 32 |
|---|
| Number | 3 |
|---|
| Page | 263-270 |
|---|
| Year/Month | 1995/3 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Recently, a method has been proposed to measure quantitative regional cerebral blood flow (rCBF) in man using N-isopropyl-p-[123I]-iodoamphetamine (IMP) and single photon emission tomography (SPECT). In this method (IMP-ARG method), a functional map of rCBF was calculated from a single SPECT scan data set, in which effects of the clearance of IMP from the brain was taken into account by employing the 2 compartment model. To avoid the procedures of frequent and/or continuous sampling of the arterial blood that was required in determination of the input function, use of a standard input function and calibrating it by one blood sampling were validated. The present study was intended to investigate the sensitivity to various sources of errors in the IMP-ARG method such as (1) effects of individual difference of the arterial input function, (2) effects of ambiguity of the regional distribution volume (Vd) of IMP, and (3) effects of inaccuracy of the SPECT measurement. It was shown in the present simulation study that errors in the calculated rCBF values were dependent on the SPECT mid-scan time (MST), and that the minimum error corresponded to the MST of approximately 30 min after the IMP infusion. With this optimal MST, errors in rCBF due to the individual difference of the input function was approximately 10%, and the errors due to the ambiguity of the Vd were approximately 8%. The total accuracy of the calculated rCBF in the IMP-ARG method was, therefore, estimated as approximately 13%. Although a relatively large error was expected at a high rCBF area, this study strongly suggested the IMP-ARG method being useful and accurate for providing the quantitative rCBF map for a clinical use. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | N-isopropyl-p-[123I]iodoamphetamine, Single photon emission computed tomography, Regional cerebral blood flow, and quantification |
|---|