| Japanese |
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| Title | 一次変性痴呆の局所脳血流量と酸素消費量および糖代謝率との関係 |
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| Subtitle | 原著 |
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| Authors | 桑原康雄*, 一矢有一*, 一宮厚**, 佐々木雅之*, 赤司祐子*, 吉田毅*, 福村利光*, 増田康治* |
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| Organization | *九州大学医学部放射線科, **精神科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 3 |
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| Page | 253-262 |
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| Year/Month | 1995/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」一次変性痴呆であるアルツハイマー型痴呆 (5例) とピック病患者 (4例) においてPETを用いて局所脳血流量, 酸素消費量および糖代謝率を測定し, 血流と代謝との関係を検討した. アルツハイマー型痴呆では対照群 (5名) と比較して, 脳血流量, 酸素消費量および糖代謝率のいずれも側頭葉から頭頂葉で低下していた. ピック病でも脳血流量, 酸素消費量および糖代謝率が前頭葉において低下していた. これらのうちでは糖代謝率の低下がアルツハイマー型痴呆とピック病のいずれにおいても最も顕著であった. 脳血流量と酸素消費量は同程度低下していた. 以上より, アルツハイマー型痴呆とピック病では糖代謝が脳血流や酸素消費量に先行して低下することが示唆され, 病変の検出には糖代謝測定が最も鋭敏と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron emission tomography, Cerebral blood flow, Cerebral oxygen metabolism, Glucose metabolism, Dementia of Alzheimer's type, Pick's disease |
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| English |
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| Title | The Relationship between the Cerebral Blood Flow, Oxygen Consumption and Glucose Metabolism in Primary Degenerative Dementia |
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| Authors | Yasuo KUWABARA*, Yuichi ICHIYA*, Atsushi ICHIMIYA**, Masayuki SASAKI*, Yuko AKASHI*, Tsuyoshi YOSHIDA*, Toshimitsu FUKUMURA*, Kouji MASUDA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Psychiatry, Faculty of Medicine Kyushu University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 3 |
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| Page | 253-262 |
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| Year/Month | 1995/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The CBF, CMRO2 and CMRGlu were measured in patients with primary degenerative dementia including 5 patients with dementia of Alzheimer's type and 4 patients with Pick's disease, and then the correlation between the cerebral blood flow and energy metabolism was evaluated. The control subjects consisted of 5 age-matched normal volunteers. The CBF, CMRO2 and CMRGlu decreased in the bilateral frontal, temporal and parietal regions in the patients with Alzheimer's dementia, while they decreased in the bilateral frontal and temporal regions in the patients with Pick's disease. Both the CBF and CMRO2 were closely correlated with each other. However, the CMRGlu was more severely impaired than the CBF or CMRO2 in both pathological conditions. These results suggested that CMRGlu began to decrease before the reduction of the aerobic metabolism and thus measuring the CMRGlu is considered to be the most sensitive method for detecting abnormal regions in primary degenerative dementia. |
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| Practice | Clinical medicine |
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| Keywords | Positron emission tomography, Cerebral blood flow, Cerebral oxygen metabolism, Glucose metabolism, Dementia of Alzheimer's type, Pick's disease |
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