| Japanese |
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| Title | 123I-MIBGおよび123I-BMIPP心筋シンチグラフィの冠動脈疾患における冠動脈病変枝診断能および左室機能評価における有用性 |
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| Subtitle | 原著 |
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| Authors | 外山卓二*, 鈴木康*, 塚越譲一*, 神田享勉*, 今井進*, 村田和彦*, 舘野円**, 遠藤啓吾**, 鈴木忠***, 星崎洋***, 大島茂****, 湯浅和男****, 谷口興一**** |
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| Authors(kana) | |
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| Organization | *群馬大学医学部第二内科, **核医学科, ***群馬大学医療技術短期大学, ****群馬県立循環器病センター |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 2 |
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| Page | 173-181 |
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| Year/Month | 1995/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心筋交感神経機能を反映する123I-MIBGおよび心筋脂肪酸代謝を反映する123I-BMIPPを用い, 冠動脈疾患の病変検出能および左室機能評価を201Tl心筋シンチグラフィと比較した. 冠動脈疾患49例に対し冠動脈病変枝診断能を運動負荷 (Ex) 201Tl像, 123I-MIBG像, 123I-BMIPP像で比較し, 左室駆出率 (LVEF) および局所壁運動を安静時 (R) 201Tl像, 123I-MIBG像, 123I-BMIPP像のそれぞれ全uptake score (US) と, 局所USで比較した. 冠動脈病変検出能の感度は123I-BMIPP像で低く, 特異度は123I-MIBGで低値であった. 正診率は123I-BMIPP像より123I-MIBG像でEx 201Tl像に近い値が得られた. LVEFと全USの相関は123I-MIBG像 (r=0.80), 123I-BMIPP像 (r=0.77) およびR 201Tl像 (r=0.68) とも良好であった. しかし, 局所USは123I-BMIPP像で最も相関がよかった. 以上より123I-MIBG像は冠動脈病変検出に, 123I-BMIPP像は左室局所壁運動評価に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-MIBG, 123I-BMIPP, Coronary artery disease, Left ventricular function, Diagnostic value |
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| English |
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| Title | Usefulness of 123I-MIBG and 123I-BMIPP Myocardial Scintigraphy for Detecting Coronary Artery Disease and for Evaluating Left Ventricular Function |
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| Authors | Takuji TOYAMA*, Yasushi SUZUKI*, Joichi TSUKAGOSHI*, Tsugiyasu KANDA*, Susumu IMAI*, Kazuhiko MURATA*, Madoka TATENO**, Keigo ENDO**, Tadashi SUZUKI***, Hiroshi HOSHIZAKI****, Shigeru OSHIMA****, Kazuo YUASA****, Koichi TANIGUCHI**** |
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| Authors(kana) | |
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| Organization | *Second Department of Internal Medicine, Gunma University School of Medicine, **Department of Nuclear Medicine, Gunma University School of Medicine, ***College of Medicine and Technology, Gunma University School of Medicine, ****Gunma Prefectural Cardiovascular Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 2 |
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| Page | 173-181 |
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| Year/Month | 1995/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We evaluated the diagnostic value of 123I-metaiodobenzylguanidine (MIBG) and 123I-labeled beta-methyliodophenyl pentadecanoic acid (BMIPP) myocardial SPECTs for evaluating coronary artery disease and left ventricular function, in comparison with the diagnostic value of 201Tl (Tl) SPECT. For forty-nine patients with coronary artery disease, resting MIBG and BMIPP SPECTs were performed to detect coronary artery stenosis, compared with the diagnostic value of exercise Tl. Left ventricular ejection fraction and regional wall motion were compared with the total US (TUS) and regional US (RUS) of resting MIBG and BMIPP SPECTs, and in turn, compared with resting Tl SPECT. The sensitivity of resting BMIPP SPECT for detecting coronary artery stenosis was lower, and the specificity of resting MIBG SPECT was lower than the other two methods. The accuracy of resting MIBG SPECT for evaluating coronary lesions was nearly the same as the accuracy of exercise Tl, but higher than that of BMIPP SPECT. Left ventricular ejection fraction was well correlated with TUS of resting MIBG SPECT (r=0.80), resting BMIPP SPECT (r=0.77), and resting Tl SPECT (r=0.68). Regional wall motion was most correlated with RUS of resting BMIPP SPECT, compared with that of resting Tl and MIBG SPECTs. These data suggest that resting MIBG SPECT is useful for detecting coronary artery disease and that resting BMIPP SPECT is valuable in evaluating regional left ventricular function. |
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| Practice | Clinical medicine |
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| Keywords | 123I-MIBG, 123I-BMIPP, Coronary artery disease, Left ventricular function, Diagnostic value |
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