| Japanese |
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| Title | シングルフォトンエミッショントモグラフ (SPECT) を用いた局所脳血流量の定量測定における誤差要因の評価 - 部分容積効果の影響と有限な初回循環透過率の影響 - |
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| Subtitle | 原著 |
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| Authors | 飯田秀博*, 成田雄一郎*, Babak A.ARDEKANI*, 畑澤順*, 中澤真弓**, 菅野巖*, 上村和夫* |
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| Authors(kana) | |
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| Organization | *秋田県立脳血管研究センター放射線医学研究部, **日本メジフィジックス株式会社学術部 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 2 |
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| Page | 155-162 |
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| Year/Month | 1995/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」2種の数値脳ファントムを用い, 局所脳血流量測定における, SPECTの有限な空間分解能に起因する部分容積効果および使用するトレーサの有限な初回循環透過率に関する誤差解析を行った. 部分容積効果に関しては, (1) マイクロスフェアモデル, (2) 内頸動脈瞬時投与クリアランス法, (3) 123I-IMP静注一回スキャン一回採血法 (IMP-ARG法), (4) 133Xe静注Kanno-Lassen法の4つのトレーサ解析モデルに対して行った. 有限な空間分解能により, 灰白質領域の放射能濃度は過小評価し, 一方白質および脳髄液領域の放射能濃度は過大評価した. 初回循環透過率が有限なトレーサを使用した血流量測定では, 虚血周辺域でのコントラストが低下し, 血流量低下領域を過小評価することが示された. 使用するトレーサおよび解析モデルにより血流量値に含まれる誤差は大きく異なるため注意を要する. |
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| Practice | 臨床医学：一般 |
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| Keywords | Regional cerebral blood flow, Partial volume effect, Single photon emission computed tomography, First-pass extraction fraction |
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| English |
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| Title | Evaluation of Partial Volume Effect in Quantitative Measurement of Regional Cerebral Blood Flow in Single Photon Emission Computed Tomography - Effects of Limited Spatial Resolution and First-Pass Extraction Fraction - |
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| Subtitle | Original Articles |
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| Authors | Hidehiro IIDA*, Yuichiro NARITA*, Babak A.ARDEKAMI*, Jun HATAZAWA*, Mayumi NAKAZAWA**, Iwao KANNO*, Kazuo UEMURA* |
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| Organization | *Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, **Nihon Medi-Physics |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 2 |
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| Page | 155-162 |
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| Year/Month | 1995/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Two numerical brain phantoms were generated in order to investigate errors which might be included in the quantitative measurement of regional CBF with use of single photon emission computed tomography (SPECT). The first phantom simulated the normal brain, and effects of the limited spatial resolution of the SPECT scanner were evaluated for 4 tracer kinetic models of the conventional microsphere model, the intra-carotid bolus injection technique of 133Xe, 133Xe Kanno-Lassen method, and the IMP-autoradiography (IMP-ARG) method. The second phantom simulated the diseased brain with middle-carotid artery (MCA) occlusion, and effects of the limited first-pass extraction fraction were investigated for the microsphere model with various permeability-surface area products. The limited spatial resolution caused systematic underestimation of the radioactivity concentration in the gray matter regions, and systematic overestimation in the low CBF regions. These errors in the original radioactivity distribution were found to cause further systematic errors in the calculated regional CBF images. It was also found that these errors were highly dependent on the tracer kinetic model employed, e.g., regional CBF values were overestimated in the clearance and the Kanno-Lassen methods compared with the conventional microsphere method, whereas values were underestimated in the IMP-ARG method. It was also shown in this study that the limited first-pass extraction fraction caused significant underestimation in the calculated rCBF values. In addition, regional contrast can be reduced when using a tracer with small PS product. This suggested a possibility of an over-sight of a small ischemia. |
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| Practice | Clinical medicine |
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| Keywords | Regional cerebral blood flow, Partial volume effect, Single photon emission computed tomography, First-pass extraction fraction |
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