| Japanese |
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| Title | 虚血性心疾患におけるTlとBMIPPの心筋内分布の定量的解析の試み |
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| Subtitle | 原著 |
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| Authors | 菊池隆徳*,***, 玉木長良*, 多田村栄二*, 工藤崇*, 服部直也*, 野原隆司**, 羽田龍彦**, 篠山重威**, 小西淳二*, 濱本研*** |
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| Authors(kana) | |
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| Organization | *京都大学医学部核医学科, **第三内科, ***愛媛大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 2 |
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| Page | 121-129 |
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| Year/Month | 1995/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患24例において運動負荷Tl心筋スキャンの早期像と遅延像を撮像し, 別の日に施行したBMIPP心筋スキャンと比較し, 各トレーサの心筋内分布を定量的に評価することを試みた. まず同心円表示において心筋を9領域に分割しそれぞれの相対的集積率を算出した. さらにTl再分布の指標 (RI) とTlとBMIPPの乖離の指標 (DI) も計算し, 視覚的評価, 壁運動スコアと対比した. 視覚的評価とはよく対応しており, 壁運動とも動きが良いほどBMIPP, Tlの集積が良い傾向があった. DIの大きい部位では壁運動が悪い傾向がみられた. Tl再分布の程度とTlとBMIPPの乖離の程度との関係は, r=0.515の相関が見られた. 定量的手法を用い壁運動と比較することで, 障害心筋の病態を詳細に検出できる可能性が示唆された. 他方, 定量的解析には物理的要因など今後の検討が必要な問題点も判明した. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-15-(p-iodophenyl)-3-methylpentadecanoic acid (BMIPP), 201Tl, SPECT, Coronary artery disease |
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| English |
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| Title | Quantitative Analysis of Myocardial Tracer Distribution in Patients with Ischemic Heart Disease : Comparison of 201Tl and 123I-15-(p-Iodophenyl)-3-Methylpentadecanoic Acid (BMIPP) |
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| Subtitle | Original Articles |
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| Authors | Takanori KIKUCHI*,***, Nagara TAMAKI*, Eiji TADAMURA*, Takashi KUDO*, Naoya HATTORI*, Ryuji NOHARA**, Tatsuhiko HATA**, Shigetake SASAYAMA**, Junji KONISHI*, Ken HAMAMOTO*** |
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| Organization | *Department of Nuclear Medicine, **Third Division, Department of Internal Medicine, Kyoto University Faculty of Medicine, ***Department of Radiology, Ehime University Faculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 2 |
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| Page | 121-129 |
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| Year/Month | 1995/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Quantitative assessment of myocardial tracer uptake in stress-delayed thallium and resting BMIPP imagings were performed in 24 patients with coronary artery disease. Each distribution was displayed on the bull's eye polar map and % uptake of each distribution was calculated as a mean value in 9 myocardial segments on the polar map. Redistribution index (% delayed uptake minus % stress uptake on thallium images) and discordance index (% delayed thallium uptake minus % BMIPP uptake) were also calculated. Each parameter was compared to the visual uptake score and wall motion score on contrast left ventriculography. Excellent correlations were obtained between % uptake and the uptake score in each tracer. The % thallium and BMIPP uptake also correlated with regional wall motion score. Furthermore, a significant correlation was observed between redistribution and discordance indexes in the mildly hypoperfused segments. These data indicate that the quantitative analysis of thallium and BMIPP distributions seems to be valuable to understand relationship between perfusion and regional wall motion. The discordant BMIPP uptake may represent asynergic but viable segments. However, several important factors, such as attenuation factor should be also taken into consideration for such quantitative analysis. |
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| Practice | Clinical medicine |
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| Keywords | 123I-15-(p-iodophenyl)-3-methylpentadecanoic acid (BMIPP), 201Tl, SPECT, Coronary artery disease |
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