| Japanese |
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| Title | 心筋梗塞巣における低用量ドブタミン負荷時の機能解析 - 99mTc-MIBI心拍同期心筋シンチグラフィを用いた局所収縮能評価 - |
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| Subtitle | 短報 |
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| Authors | 汲田伸一郎*, 水村直*, 木島鉄仁*, 隈崎達夫*, 酒井俊太**, 哲翁弥生**, 草間芳樹**, 宗像一雄** |
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| Organization | *日本医科大学放射線科, **第一内科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 1 |
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| Page | 75-79 |
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| Year/Month | 1995/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」従来より, 心筋梗塞部のviability評価として201TlCl心筋シンチが汎用されているが, 近年, 低用量ドブタミン (DOB) 負荷エコーを用いた心機能面よりの評価も行われている. 著者らは心筋梗塞8例に対し, 安静時および低用量 (4〜6μg/kg/min) DOB負荷時の99mTc-MIBI心拍同期心筋SPECTデータ収集を行った. 次いで短軸像における拡張末期 (ED), 収縮末期 (ES) 像より, 左室収縮に伴う心筋count上昇率 (%WT=ES-ED/ED×100) を算出し, 安静時およびDOB負荷時の局所収縮能の比較検討を行った. 同一症例に対し同用量のDOB負荷エコーを行ったところ, 負荷時に壁運動改善を認めた梗塞部 (WM(+)) は15セグメント, 認めなかった梗塞部 (WM(-)) は5セグメントであった. 安静時およびDOB負荷時の%WTは, 梗塞部 (WM(-)) では, それぞれ29.1±6.2, 33.2±2.4と差異を認めなかったのに対し, 梗塞部 (WM(+)) では26.8±9.8, 40.0±12.3と負荷時に有意な上昇を示した (p<0.05). DOB負荷併用のMIBI心拍同期SPECTデータを用いた収縮能解析は, DOB負荷エコーの壁運動評価を反映しており, かつ定量性に富む, 有用な検査手法であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MIBI, Dobutamine, Gated myocardial scintigraphy, Myocardial infarction |
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| English |
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| Title | Low-Dose Dobutamine Stress Test for the Evaluation of Cardiac Function Using ECG-gated SPECT Scintigraphy with 99mTc-MIBI |
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| Authors | Shin-ichiro KUMITA*, Sunao MIZUMURA*, Tetsuji KIJIMA*, Tatsuo KUMAZAKI*, Shunta SAKAI**, Yayoi TETSUOU**, Yoshiki KUSAMA**, Kazuo MUNAKATA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **First Department of Internal Medicine, Nippon Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 1 |
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| Page | 75-79 |
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| Year/Month | 1995/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Although 201TlCl myocardial scintigraphy has so far been widely used for the evaluation of the viability of the myocardial infarcted area, functional evaluation using low dose dobutamine (DOB) loaded echography also became recently available. We performed 99mTc-MIBI gated SPECT on eight cases of myocardial infarction at rest and low dose (4-6μg/kg/min) DOB-loading and related data were collected. Next, we calculated myocardial count increase rate (%WT=ES-ED/ED×100) with left ventricular contraction from end-diastolic (ED) and end-systolic (ES) pictures in short-axial image, and made a comparative examination of regional contractilities at rest and DOB-loading. DOB-loaded echography performed on the same cases at the same dose revealed 15 segments as infarcted area (WM(+)) presenting improvement in wall movement at loading and 5 segments as infarcted area (WM(-)) presenting no such improvement, and %WT at rest and loading were 29.1+-6.2 and 33.2+-2.4 for (WM(-)) and 26.8+-9.8 and 40.0+-12.3 for (WM(+)), indicating a significant increase (p<0.05) at loading. Contractility analysis using MIBI gated SPECT in combined use of DOB-loading was considered as a useful method of examination in view of its reflectionality in the evaluation of the wall movement in DOB-loaded echography and of its high quantitativity. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MIBI, Dobutamine, Gated myocardial scintigraphy, Myocardial infarction |
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