| Japanese |
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| Title | 201Tl SPECTによる家兎VX-2腫瘍の放射線照射後の残存度評価 - X線CTおよび病理所見との比較 - |
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| Subtitle | 原著 |
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| Authors | 清水正司*, 瀬戸光*, 蔭山昌成*, 呉翼偉*, 永吉俊朗*, 神前祐一*, 森尻実*, 野村邦紀*, 渡辺直人*, 柿下正雄* |
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| Authors(kana) | |
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| Organization | *富山医科薬科大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 1 |
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| Page | 41-49 |
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| Year/Month | 1995/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」家兎VX-2腫瘍に放射線照射を行い, 腫瘍残存度の評価における201Tl SPECTの有用性を検討した. 20羽の家兎を対照 (N) 群, 20Gy照射 (治療効果なし : A群, 治療効果あり : B群) および40Gy照射 (C) 群の4群に分けて評価した. 経時的に201Tl SPECT, X線CTを施行し, 同時に病理組織標本も得た. N群では体積は4週後まで増加したが, 201Tl摂取率は2週後まで増加し, その後やや減少した. A群でも体積は4週後まで増加したが, 201Tl摂取率は1週後に一時的に減少した後, 4週後まで増加した. B群では体積は1週後に一時的に増加した後, 4週後まで減少した. 201Tl摂取率は4週後まで減少した. C群では体積および201Tl摂取率とも4週後まで減少した. B群, C群では, 体積の減少より摂取率の低下が早期に認められ, 1週後で有意差 (p<0.01) が認められた. 201Tl SPECTは放射線照射後の腫瘍残存度の評価に有用であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 201Tl chloride, SPECT, VX-2 tumor, Tumor viability, X-ray CT |
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| English |
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| Title | Assessment of Tumor Viability by 201Tl SPECT in VX-2 Tumor-Bearing Rabbits after Irradiation : Comparison with X-ray CT and Pathohistologic Findings |
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| Subtitle | Original Articles |
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| Authors | Masashi SHIMIZU, Hikaru SETO, Masanari KAGEYAMA, Yi-wei WU, Toshiro NAGAYOSHI, Yuichi KAMISAKI, Makoto MORIJIRI, Kuninori NOMURA, Naoto WATANABE, Masao KAKISHITA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 1 |
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| Page | 41-49 |
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| Year/Month | 1995/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to evaluate 201Tl SPECT for the assessment of tumor viability after radiation therapy. Twenty rabbits were implanted with VX-2 tumor in the left femoral muscles and were classified into four groups as follows : normal control group (N), 20 Gy irradiated response group (A), 20 Gy irradiated non-response group (B), and 40 Gy irradiated group (C). Eight days after implantation, 201Tl SPECT and CT studies were performed to assess the changes in 201Tl uptake and tumor volume at 0, 1, 2, 3, and 4 weeks after single irradiation. Histologic specimens were also taken. In group N tumors continued to increase in volume, but 201Tl uptake showed a steady decrease after 2 weeks. In group A tumors continued to increase in volume, but 201Tl uptake showed a transient decrease at 2 weeks, then a steady increase. In group B tumors showed a transient increase in volume at 2 weeks, then a continuous decrease, but 201Tl uptake showed a continuous decrease throughout the study. In group C there was a continuous decrease both in volume and 201Tl uptake with the later more prominent. 201Tl uptake was decreased earlier than tumor volume both in group B and C, at one week that was significant (p<0.01). 201Tl uptake by tumor reflects the burden of viable tumor on histology ; therefore 201Tl SPECT is of great use in assessing the therapeutic effects on tumors. |
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| Practice | Clinical medicine |
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| Keywords | 201Tl chloride, SPECT, VX-2 tumor, Tumor viability, X-ray CT |
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