| Japanese |
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| Title | 抗リン脂質抗体症候群の脳血流SPECT (123I-IMP) による検討 |
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| Subtitle | 原著 |
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| Authors | 加藤徹*, 南部一郎*, 遠山淳子*, 大場覚* |
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| Organization | *名古屋市立大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 1 |
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| Page | 31-40 |
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| Year/Month | 1995/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」抗リン脂質抗体症候群 (antiphospholipid syndrome : APS) と診断され, 軽度の頭痛を訴えていた比較的軽症の5例について123I-IMPによる脳血流SPECTを施行した. いずれの症例も脳内アイソトープの分布は不均一で, 複数部位に脳血流低下が疑われた. 特に, 2例は明らかな血流低下部位を認め, その1例は両側の後頭葉と右側側頭葉に, もう1例は両側の後頭葉に血流低下部位を認めた. また同時に施行した3例のmicrosphere法持続動脈採血による脳血流定量値はいずれも正常範囲内であった. 5例ともCTおよびMRIもほぼ同時期に行ったが, 有意な異常は認められなかった. また全例他覚的神経学的異常所見は認められなかった. 抗リン脂質抗体症候群では動静脈血栓症や血管攣縮を起こしやすいと考えられるので, 器質的脳血管障害を防ぐ意味で, 同疾患と診断されている患者が頭痛などの症状を訴えた場合には, 脳血流SPECTを施行すべきであると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Antiphospholipid syndrome, 123I-IMP, Cerebral blood flow |
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| English |
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| Title | Evaluation of Cerebral Perfusion Imaging with N-Isopropyl-p-[123I]Iodoamphetamine (IMP) in the Cases of Antiphospholipid Syndrome |
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| Subtitle | Original Articles |
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| Authors | Toru KATO, Ichiro NANBU, Junko TOHYAMA, Satoru OHBA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Nagoya City University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 1 |
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| Page | 31-40 |
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| Year/Month | 1995/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Five cases of antiphospholipid syndrome with mild headache, but without any neurological deficits and abnormal findings by CT and MRI, were examined by cerebral blood perfusion SPECT using N-isopropyl-p-[123I]iodoamphetamine (IMP). Although three cases were performed quantification of cerebral blood flow with a microsphere method simultaneously, their values were within normal limits. Two of them showed focal low perfusion areas. One case had relatively low perfusion areas in the bilateral occipital lobes and the right temporal lobe, which improved after treatment. One of two had low perfusion in the bilateral occipital lobes. Other three cases only showed ununiformity of radioisotope uptake on the cerebral blood perfusion SPECT. Low perfusion areas in antiphospholipid syndrome might be caused by microarterial thrombosis, microvenous thrombosis or spasms, although they could be reversible. As early detection of cerebral abnormality admit to protect irreversible progress of cerebral blood flow, cerebral blood flow SPECT should be performed in cases of antiphospholipid syndrome with neurological complainments. |
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| Practice | Clinical medicine |
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| Keywords | Antiphospholipid syndrome, 123I-IMP, Cerebral blood flow |
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