| Japanese |
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| Title | 骨転移診断に対する201Tl-chlorideシンチグラフィの臨床的有用性 |
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| Subtitle | 原著 |
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| Authors | 小山雅司* |
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| Organization | *名古屋市立大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 1 |
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| Page | 9-18 |
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| Year/Month | 1995/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」201Tlシンチグラフィを骨転移診断に応用し, その所見と有用性について検討した. 骨転移118病変に対する201Tlシンチグラフィ (全身像) の陽性率は, early scanで76.3%, delayed scanで74.6%であった. 原発巣による有意差はみられなかったが, 転移の大きさには依存し (p<0.05), 7cm3を超える病変の陽性率は90.5%であった. ただし周囲に生理的集積の多い脊椎や胸郭病変ではSPECTによる評価が望まれた. 骨転移 (n=86) のR. Indexは-21.4±47.1で, 原発の組織型別では肺扁平上皮癌や乳癌の転移に比し, 肺腺癌や肺小細胞癌の転移は高値であった. 非転移病変では3病変の脊椎カリエスを含め, early scanで5病変, delayed scanで4病変に201Tlの集積が認められたが, このほかの非転移病変には集積がみられなかった. 以上の結果より, 201Tlシンチグラフィは骨転移の正診率向上に寄与でき, 骨転移診断に有用な検査法と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 201Tl-chloride, Bone metastasis, Vertebral compression fracture, 99mTc-HMDP, Bone Imaging |
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| English |
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| Title | Clinical Usefulness of 201Tl-Chloride Scintigraphy for the Diagnosis of Bone Metastases |
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| Subtitle | Original Articles |
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| Authors | Masashi KOYAMA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Nagoya City University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 1 |
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| Page | 9-18 |
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| Year/Month | 1995/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Fifty-five patients with bone lesions underwent 201Tl-chloride (201TlCl) scintigraphy to evaluate its findings and usefulness for the diagnosis of bone metastases. 201TlCl scintigraphy was performed 15 minutes (early scan) and 2 hours (delayed scan) after intravenous administration of 5.55 MBq/kg of 201Tl-chloride. To evaluate the degree of tracer retention at the lesions, we calculated retention index after setting regions of interest in each lesions demonstrated tracer uptake in both early and delayed scans. Among 118 lesions of pathologically and/or clinically comfirmed bone metastases, 201TlCl planar images disclosed 90 (76.3%) and 88 (74.6%) lesions on early and delayed scans, respectively. SPECT images were preferable for the evaluation of the lesions in the spine, the thoracic cage and pelvis. Correlation of tumor size with findings on 201TlCl images demonstrated 90.5% sensitivity for the metastases more than 7 cm3. No correlational difference was seen in the sensitivity depending on primary cancers. The overall retention index of bone metastases was -21.4+-47.1. Bone metastases of pulmonary adenocarcinomas and small cell carcinomas demonstrated higher retention index than those of pulmonary squamous cell carcinomas and breast cancers. On 201TlCl images, no abnormal tracer uptakes were seen in benign lesions detected by 99mTc-hydroxymethylene diphosphonate (99mTc-HMDP) images except 5 lesions. The retention index of these benign lesions demonstrated abnormal uptakes on 201TlCl images was -48.3+-15.0, which found no significant difference between that of metastases. In cases of vertebral compression fractures, abnormal tracer uptakes were demonstrated in 9 of the 12 pathologic fractures against 2 of the 10 benign ones. Those 2 benign fractures proved to be vertebral tuberculosis. These results suggest 201TlCl scintigraphy can find out false positive lesions of 99mTc-HMDP scintigraphy and contribute the diagnosis of bone metastases with combination of other images. |
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| Practice | Clinical medicine |
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| Keywords | 201Tl-chloride, Bone metastasis, Vertebral compression fracture, 99mTc-HMDP, Bone imaging |
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