| Japanese |
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| Title | 131I-MIBGによる悪性褐色細胞腫の治療効果 - 長期経過観察の結果 - |
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| Subtitle | 原著 |
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| Authors | 日下部きよ子*, 金谷和子*, 金谷信一*, 矢崎恵理子*, 中野敬子*, 松本信彦*, 小林秀樹*, 牧正子*, 伊藤悠基夫**, 小原孝男**, 野村馨***, 出村博***, 小口寿夫**** |
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| Authors(kana) | |
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| Organization | *東京女子医科大学放射線科, **内分泌外科, ***内分泌内科, ****信州大学医学部内科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 12 |
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| Page | 1495-1502 |
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| Year/Month | 1994/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」悪性褐色細胞腫で131I-MIBG治療を受け, 初回治療から5年以上経過した4例について治療効果を評価した. 年齢は41歳から69歳までの平均53歳で, 男性2例と女性2例である. 4例中3例は4年から8年前に原発腫瘍の摘出術が施行されており, 1例は副腎性褐色細胞腫, そして2例は後腹膜のパラガングリオーマであった. 1例は骨病巣の生検からパラガングリオーマと診断され, 心膜と癒着して摘出困難な縦隔腫瘍が原発巣と考えられた. いずれもトレーサ量の131I-MIBGで病巣への集積が見られる症例で, 1回3.7GBqの131I-MIBGで治療された. 2例は2回の治療が, そして1例は3回の治療が施行された. 4例中1例は3回の131I-MIBG治療で総計150Gy以上の腫瘍吸収線量となり, 明らかな治療効果が得られ, 初回治療から5.1年を経ている. しかし他の3例はほとんど効果を示さず, 初回131I-MIBG治療後, 2.6年から4.1年で死亡した. 131I-MIBG治療は悪性褐色細胞腫の症例のうち, 高度の集積を呈する症例では有用な治療手段となり得ると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 131I-MIBG therapy, Malignant pheochromocytoma, Radioisotope therapy, Radiation absorbed dose |
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| English |
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| Title | Therapeutic Effectiveness of 131I-MIBG on Malignant Pheochromocytoma - Results of Long Follow-up - |
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| Subtitle | Original Articles |
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| Authors | Kiyoko KUSAKABE*, Kazuko KANAYA*, Shinichi KANAYA*, Eriko YAZAKI*, Keiko NAKANO*, Nobuhiko MATSUMOTO*, Hideki KOBAYASHI*, Masako MAKI*, Yukio ITOU**, Takao OBARA**, Kaoru NOMURA***, Hiroshi DEMURA***, Toshio OGUCHI**** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Endocrine Surgery, ***Department of Endocrine Internal Medicine, Tokyo Women's Medical College, ****Department of Internal Medicine, Shinshu University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 12 |
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| Page | 1495-1502 |
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| Year/Month | 1994/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The therapeutic response of 131I-MIBG was evaluated in 4 patients with malignant pheochromocytoma who had been treated with 131I-MIBG and followed-up over 5 years. The patients were 2 men and 2 women with ages ranging from 41 to 69 years old (mean 53 years). The primary tumors in 3 of 4 patients had been resected four to eight years before 131I-MIBG treatment. One patient was diagnosed as adrenal pheochromocytoma, and two were retroperitoneal paraganglioma. And in one patient, the resection of primary mediastinal tumor was not performed due to the adhesion to pericardium but the diagnosis of paraganglioma was obtained by biopsy of bone lesion. All patients showed the clear accumulation of 131I-MIBG in tumor on scintigraphy. The number of doses of 131I-MIBG ranged from one to three times with 3.7 GBq per administration and a cumulative activity from 3.7 to 11.1 GBq. Treatement effect was obvious in one patient with lung, bone, and lymphnode metastases whose cumulated absorbed dose with 11.1 GBq of 131I-MIBG exceeded over 150 Gy. At the present time, the duration of survival since the beginning of initial 131I-MIBG therapy is over 5 yrs. The other three patients, however, showed little effects, and died with the disease in 2.6 to 4.1 years after the initial 131I-MIBG therapy. 131I-MIBG will become a promising agent for therapy in patients with malignant pheochromocytoma with high degree of accumulation. |
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| Practice | Clinical medicine |
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| Keywords | 131I-MIBG therapy, Malignant pheochromocytoma, Radioisotope therapy, Radiation absorbed dose |
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