| Japanese |
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| Title | 呼吸器核医学 - 最近の動向 - |
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| Subtitle | 総説 |
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| Authors | 川上憲司* |
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| Authors(kana) | |
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| Organization | *東京慈恵会医科大学放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 11 |
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| Page | 1385-1390 |
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| Year/Month | 1994/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」呼吸器核医学は, 換気・血流といった呼吸生理の画像化を中心として発展してきたが, 近年は非呼吸性肺機能の解析にも応用が進みつつある. 放射性医薬品としては従来133Xe, 81mKrの利用が多いが, 99mTc-テクネガスも認可され普及しつつある. 疾患対象も, 肺塞栓症などの絶対適応のほか, 喘息, 間質性肺炎, びまん性汎細気管支炎などの治療効果把握にも有用視されている. 非呼吸性肺機能の画像化も67Gaはじめ近年盛んに行われるようになり, 他の手法では得ることのできない新しい情報の収集が可能となってきた. 特に, 粘液線毛運動, 肺上皮透過性の評価は今後の呼吸器核医学の課題と思われる. 一方, 腫瘍性病変に関しても67Gaから201Tlに代わりつつあり, さらに新しい試みとして, 種々のモノクローナル抗体, 99mTc-MIBIなどが試みられ, 好成績が得られつつある. 本稿ではこれらのトピックスについて要点を述べた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Pulmonary nuclear medicine, Ventilation, Perfusion scintigraphy, Pulmonary epithelial permeability, Tumor imaging of lung cancer |
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| English |
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| Title | New Trends of Pulmonary Nuclear Medicine |
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| Subtitle | |
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| Authors | Kenji KAWAKAMI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Jikei University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 11 |
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| Page | 1385-1390 |
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| Year/Month | 1994/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Radionuclide study for pulmonary diseases is divided in three large categories, respiratory function of ventilation and perfusion, non-respiratory function such as mucocilliary movement, epithelial permeability, and tumor imaging. Ventilation and perfusion scintigraphy are useful for the diagnosis and follow up of pulmonary embolism, obstructive lung disease, etc. A new ventilatory agent, 99mTc-technegas, is now available and many studies with this gas have been reported. As a tumor imaging agent, 201TlCl is coming popular for the diagnosis of lung cancer and early detection of metastatic lesions. Tumor detection with 99mTc-MIBI is also tried to differentiate the malignant tumor from the benign process. As applications of nuclear medicine for the interstitial lung disease, 67Ga scintigraphy and measurement of epithelial permeability with 99mTc-DTPA are available for an evaluation of activity of the disease and damage of lung epithelial integrity. In this report, significance and useful application of the radionuclide methods were summarized. |
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| Practice | Clinical medicine |
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| Keywords | Pulmonary nuclear medicine, Ventilation, Perfusion scintigraphy, Pulmonary epithelial permeability, Tumor imaging of lung cancer |
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