| Japanese |
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| Title | "ポルフィリン誘導体" 99mTc-STA-R12の有用性 |
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| Subtitle | 技術報告 |
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| Authors | 中島進*, 秀毛範至**, 油野民雄**, 石川幸男**, 佐藤順一**, 阪田功***, 竹村健**** |
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| Organization | *旭川医科大学附属病院手術部, **放射線部, ***東洋薄荷工業, ****北海道大学電子科学研究所 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 11 |
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| Page | 1379-1383 |
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| Year/Month | 1994/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」ポルフィリン誘導体の癌組織集積性のメカニズムが明らかとなり再び注目を浴びてきている. われわれはすでにMn金属ポルフィリンを用いた腫瘍シンチ剤111In-ATN10の優れた腫瘍描出能を報告したが, 今回は新たに合成した4種類の誘導体 (STA-R12, STA-R21, STA-R101, ATN-12) の腫瘍描出能を検討し, 光化学反応を利用して合成されたSTA-R12が最も優れていることを見いだした. CDF1マウス移植コロン26腫瘍を用いた実験では本剤静注後, 腫瘍部の放射能は2時間後まで増加を示し腫瘍部分に選択的に取り込まれることが明らかとなった. これに反して, 腫瘍以外の各臓器の取り込みは経時的に減少した. STA-R12の腫瘍および肝臓以外の組織からの早い排泄は本誘導体が99mTc標識イメージング剤として有用であることを示唆している. |
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| Practice | 臨床医学：一般 |
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| Keywords | STA-R12, Mn-metalloporphyrin, Tumor-imaging agent |
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| English |
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| Title | Usefulness of Newly Developed 99mTc-Labeled STA-R12 for Tumor Imaging |
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| Authors | Susumu NAKAJIMA*, Noriyuki SHUKE**, Tamio ABURANO**, Satio ISHIKAWA**, Juniti SATO**, Isao SAKATA***, Takeshi TAKEMURA**** |
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| Authors(kana) | |
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| Organization | *Division of Surgical Operation, **Department of Radiation, Asahikawa Medical College, ***Toyo Hakka Kogyo, ****Institute of Electronic Science of Hokkaido University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 11 |
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| Page | 1379-1383 |
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| Year/Month | 1994/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We synthesized four new tumor imaging agents, 99mTc-labeled metalloporphyrins (99mTc-STA-R12, -STA-R21, -STA-RN101 and -ATN-12) for the tumor imaging. We compared the differences of tumor imaging potency among these agents in CDF1 mice implanted with colon 26 tumor. Tumor images with these agents were obtained by using digital γ-camera (RC135-E, Hitachi, Tokyo) and the biodistributions were analyzed by computerlized medical radionuclide imageanalyser (RP-200, Hitachi, Tokyo). The highest tumor organ ratio and the excellent tumor image were obtained by 99mTc-STA-R12 (13,17-Bispropanyl aspartic acid-3-ethenyl-8-[N,N',N",N"-tetrakis (carboxylmethyl-2,7,12,18-tetramethyl-porphyrinato]-manganese (III). The maximum concentration of 99mTc-STA-R12 in tumor tissue was observed at around 120 minutes after i.v. injection. On the contrary, the uptake rates of other organs and tissues such as liver, brain, muscle, lung, bone and blood continuously decreased. The rapid accumulation of STA-R12 in cancer tissue and the clearance from other tissue suggested a potential usefulness of this compound for tumor imaging agent. |
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| Practice | Clinical medicine |
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| Keywords | STA-R12, Mn-metalloporphyrin, Tumor-imaging agent |
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