| Japanese |
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| Title | 99mTc-MIBI 2回分注法による運動負荷 - ニトログリセリン (NTG) 心筋イメージ法の臨床的有用性 |
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| Subtitle | 原著 |
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| Authors | 塩谷英之*, 上野洋*, 鹿住敏*, 松永公雄* |
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| Organization | *兵庫県立成人病センター内科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 11 |
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| Page | 1329-1334 |
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| Year/Month | 1994/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-MIBIを用いた新しい1日イメージ法 (運動負荷-NTG心筋シンチ) を考案し, 虚血性心疾患の診断に対する有用性を通常の運動負荷Tl心筋シンチと比較検討した. 対象は虚血性心疾患21例で全例に負荷Tl心筋シンチと運動負荷-NTG MIBI心筋イメージを撮像した. 運動負荷-NTG MIBI心筋イメージは運動負荷中止1分前にMIBI 150 MBqを静注し, その5分後にNTGを1錠舌下させ, 舌下1時間後に初期イメージを撮像した. 撮像後直ちにMIBI 450 MBqを再静注し1時間後に安静時画像を撮像した. Tl心筋シンチは負荷像および3時間後に再分布像を撮像した. 冠動脈病変診断に関してMIBIイメージではSensitivity 75%, Specificity 90%と, Tlイメージと同等の診断能が得られた (Tlイメージ : Sensitivity 67%, Specificity 93%). 負荷時に灌流欠損の見られた部位では, Tlイメージでの再分布およびMIBI安静時像でのdefectの改善は74%で一致したが, 一部の例においてMIBIイメージでのみdefectの改善が認められた. 運動負荷-NTG MIBIイメージは冠動脈病変および心筋viabilityの診断にTl法と同等の有用性がある可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MIBI, 201Tl, Nitroglycerine |
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| English |
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| Title | Exercise-Nitroglycerine Technetium-99m-2-Methoxy Isobutyl Isonitrile Tomoscintigraphic Imaging for Identifying Diseased Coronary Vessels : Comparison with Thallium-201 Standard Exercise-Redistribution Study |
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| Subtitle | Original Articles |
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| Authors | Hideyuki SHIOTANI, Hiroshi UENO, Tsutomu KAZUMI, Kimio MATSUNAGA |
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| Organization | Department of Cardiology, Hyogo Medical Center for Adults |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 11 |
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| Page | 1329-1334 |
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| Year/Month | 1994/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A same-day double injection protocol employing 99mTc-methoxy isobutyl isonitrile (MIBI) and myocardial single-photon emission computed tomography (SPECT) for detecting coronary heart disease (CAD) was assessed in 21 patients. Our exercise-nitroglycerin (NTG) MIBI study was performed as follows : 150 MBq 99mTc-MIBI was injected at peak exercise, and after 5 minutes 0.3 mg of NTG was sublingually administered. Then, SPECT was performed 1 hour later. Immediately after the 1st imaging, patients were injected of 750 MBq 99mTc-MIBI and were reimaged 1 hour later. Within 1 month, all patients were underwent standard exercise redistribution SPECT thallium (Tl) study. Of the 126 myocardial segments evaluated, 81 were judged as normal by both techniques, while the presence of stress defects were demonstrated in 37 segments (Agreement : 94%). Vessel sensitivities were 75% by MIBI and 67% by Tl. Specificities were 90% by MIBI and 93% by Tl. For the pattern of reversibility in myocardial segments with stress defects, the agreement was 73%. In conclusion, our exercise-NTG MIBI may be safely performed, giving results equivalent to those of standard stress-redistribution thallium studies. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MIBI, 201Tl, Nitroglycerine |
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