| Japanese |
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| Title | 動脈一点採血によるN-isopropyl-p-[123I]iodoamphetamineとSPECTを用いた簡便な脳血流測定法 - One-point sampling法 - |
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| Subtitle | 原著 |
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| Authors | 小田野行男*, 大久保真樹**, 高橋直也*, 野口栄吉*, 大滝広雄*, 羽田野政義*, 山崎芳裕*, 樋口健史* |
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| Authors(kana) | |
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| Organization | *新潟大学医学部放射線医学教室, **新潟大学医療技術短期大学部診療放射線技術学科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 10 |
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| Page | 1219-1226 |
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| Year/Month | 1994/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-p-[123I]iodoamphetamineを静注したあと, 動脈血を一時点で採血して持続動脈採血の代用とする, 侵襲性の少ない簡便な新しい定量的脳血流量測定法(one-point sampling法)を考案した. マイクロスフェアーモデルによる従来の脳血流測定法では, 脳への入力関数の積分値, すなわち持続採血した動脈血中の123I-IMPの総放射能にオクタノール抽出率を乗じた値が必要である. 本法ではこの値を回帰直線を用いて一時点で採血した動脈血から推定する. まず, 回帰直線の設定と一点採血時刻の最適化を行った. 123I-IMP静注後5分間の持続動脈採血とオクタノール抽出により得られた入力関数の積分値と, 時刻tで一点採血した動脈血中の123I-IMPの放射能Ca(t)との相関を検討し, 回帰直線を求めた. この回帰直線を用いてCa(t)から積分値を算出したときの誤差率を検討したところ, 123I-IMP静注6分後に採血した場合に誤差率は最小(8.1%)となった. その際には, 一点採血した試料のオクタノール抽出率を用いる必要はなかった. 次に, 一点採血の時刻が前後した場合の影響を検討した結果, 6分から±1分以内の変動であれば約3%の誤差率で補正が可能であった. 測定値は133Xe吸入法SPECTともよく相関(r=0.773)した. 本法は, 侵襲性が少なく簡便でオクタノール処理も不要で精度よく局所脳血流が測定でき, しかも心肺系疾患や喫煙の影響をうけにくい脳血流測定法である. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, Regional CBF, SPECT, Microsphere model. |
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| English |
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| Title | Quantifying Regional Cerebral Blood Flow with N-Isopropyl-p-[123I]Iodoamphetamine and SPECT by One-Point Sampling Method |
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| Authors | Ikuo ODANO*, Masaki OHKUBO**, Naoya TAKAHASHI*, Eikichi NOGUCHI*, Hiro OHTAKI*, Masayoshi HATANO*, Yoshihiro YAMAZAKI*, Takeshi HIGUCHI* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Niigata University School of Medicine, **Department of Radiological Technology, College of Biomedical Technology, Niigata University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 10 |
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| Page | 1219-1226 |
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| Year/Month | 1994/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We developed a new non-invasive technique; one-point sampling method, for quantitative measurement of regional cerebral blood flow (rCBF) with N-isopropyl-p-[123I]iodoamphetamine and SPECT. Although the continuous withdrawal of arterial blood and octanol treatment of the blood are required in the conventional microsphere method, the new technique does not require these two procedures. The total activity of 123I-IMP obtained by the continuous withdrawal of arterial blood is inferred by the activity of 123I-IMP obtained by the one point arterial sample using a regression line. To determine when one point sampling time was optimum for inferring integral input function of the continuous withdrawal and whether the treatment of sampled blood for octanol fraction was required, we examined a correlation between the total activity of arterial blood withdrawn from 0 to 5 min after the injection and the activity of one point sample obtained at time t, and calculated a regression line. As the results, the minimum % error for the inference using the regression line was obtained at 6 min after the 123I-IMP injection, moreover, the octanol treatment was not required. Then examining an effect on the values of rCBF when the sampling time was deviated from 6 min, we could correct the values in approximately 3% error when the sample was obtained at 6+-1 min after the injection. The one-point sampling method provides accurate and relatively non-invasive measurement of rCBF without octanol extraction of arterial blood. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, Regional CBF, SPECT, Microsphere model. |
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