| Japanese |
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| Title | 低心機能虚血性心疾患および拡張型心筋症の123I-MIBG初期心筋摂取率と心筋クリアランスの検討 - 左室機能との関連について - |
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| Subtitle | 原著 |
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| Authors | 小林秀樹*, 百瀬満*, 柏倉健一*, 松本延介*, 日下部きよ子*, 斉藤克己**, 浅野竜太**, 堀江俊伸**, 細田瑳一** |
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| Authors(kana) | |
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| Organization | *東京女子医科大学放射線科, **循環器内科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 10 |
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| Page | 1177-1183 |
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| Year/Month | 1994/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」低心機能虚血性心疾患(IHD)および拡張型心筋症(DCM)を対象にMIBG心筋シンチグラフィを施行し, MIBG初期心筋摂取率, 心筋/縦隔比(H/M), MIBG心筋クリアランスと左室機能の関連について検討した. 初期像, 遅延像のH/Mは, IHD群, DCM群ともに対照群より低値であったが, MIBG初期心筋摂取率はDCM群, IHD群のいずれも対照群と差がなかった. MIBG心筋クリアランスは, IHD群, DCM群が対照群に比べ有意に高値を示し, 全対象例のMIBG心筋クリアランスと左室駆出率のあいだに負の相関(r=0.78)が認められた. 遅延像のH/Mは, 左室の拡大, MIBGの初期心筋摂取, MIBG心筋クリアランスに依存している指標で, MIBG初期心筋摂取率が低下した症例の評価には注意が必要と考えられた. MIBG心筋クリアランスは左室機能の低下と密接に関連している指標であり, 各症例ごとのMIBG心筋クリアランスの臨床的意義についてさらに検討が必要と考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-metaiodobenzylguanidine (MIBG), Initial myocardial uptake, Myocardial clearance, Left ventricular dysfunction, Dilated cardiomyopathy. |
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| English |
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| Title | Initial Myocardial Uptake and Myocardial Clearance of 123I-Metaiodobenzylguanidine in Patients with Ischemic Heart Disease of Left Ventricular Dysfunction and Dilated Cardiomyopathy |
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| Subtitle | Original Articles |
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| Authors | Hideki KOBAYASHI*, Mitsuru MOMOSE*, Kenichi KASHIKURA*, Nobusuke MATSUMOTO*, Kiyoko KUSAKABE*, Katsumi SAITOU**, Toshinobu HORIE**, Ryuta ASANO**, Saichi HOSODA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Cardiology, Tokyo Women's Medical College Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 10 |
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| Page | 1177-1183 |
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| Year/Month | 1994/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We studied initial myocardial uptake and myocardial clearance of 123I-metaiodobenzylguanidine (MIBG) in patients with ischemic heart disease of left ventricular dysfunction and dilated cardiomyopathy. Eleven patients with ischemic heart disease of left ventricular dysfunction (IHD group), 6 patients with dilated cardiomyopathy (DCM group) and 7 control cases (control group) were studied. Heart to mediastinum activity ratio (H/M) of early and delayed image was significantly lower in the IHD and DCM groups than in the control group. Although initial myocardial uptake of MIBG showed no significant difference among three groups, myocardial clearance of MIBG was significantly higher in the IHD (35+-11%) and DCM (48+-13%) groups than that in the control group (19+-10%). H/M of delayed image was related to the left ventricular size, initial MIBG uptake and MIBG myocardial clearance. Negative correlation was observed between MIBG myocardial clearance and left ventricular ejection fraction in all cases. In conclusion, initial myocardial uptake of MIBG were not decreased in patients with IHD and DCM. Enhanced myocardial clearance of MIBG was observed not only in patients with DCM but also in patients with IHD. |
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| Practice | Clinical medicine |
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| Keywords | 123I-metaiodobenzylguanidine (MIBG), Initial myocardial uptake, Myocardial clearance, Left ventricular dysfunction, Dilated cardiomyopathy. |
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