| Japanese |
|---|
| Title | 99mTc-HMPAO脳SPECTの平衡時静脈血赤血球カウントによる標準化の試み |
|---|
| Subtitle | 短報 |
|---|
| Authors | 田中良一*, 林田孝平*, 広瀬義晃*, 石田良雄*, 宮下光太郎**, 神長達郎***, 西村恒彦*** |
|---|
| Authors(kana) | |
|---|
| Organization | *国立循環器病センター放射線診療部, **脳血管内科, ***大阪大学医学部トレーサ情報解析 |
|---|
| Journal | 核医学 |
|---|
| Volume | 31 |
|---|
| Number | 9 |
|---|
| Page | 1113-1116 |
|---|
| Year/Month | 1994/9 |
|---|
| Article | 報告 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」99mTc-HMPAOの脳および血中での動態を利用し, 脳SPECTにおいて平衡時静脈血赤血球カウントにて標準化する方法を開発した. 脳血管障害7例で, PET検査終了時に99mTc-HMPAOを急速静注し経時的に動脈血を採血し, 積分により求めた入力積算値と静注4時間後平衡時の赤血球カウントとの相関は高かった(r=0.93). 99mTc-HMPAO静注4時間後に脳SPECTを撮像し, 体軸断層像上に44か所(皮質36か所, 深部基底核領域8か所)の関心領域を設定し, そのカウントを平衡時静脈血中カウントにて補正した. PET C15O2ガス吸入により脳血流量測定した体軸断層像に同様の関心領域を設定し比較すると相関は皮質(r=0.80), 深部基底核領域(r=0.67)であった. 本法により99mTc-HMPAO脳SPECTの局所カウントを平衡時静脈血赤血球カウントにて標準化することにより絶対値としての脳血流測定の可能性が示された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Quantitative analysis, rCBF, 99mTc-HMPAO, Brain SPECT. |
|---|
| English |
|---|
| Title | Standardization of Regional Cerebral Count Corrected by Equilibrium Blood Count with 99mTc-HMPAO Brain SPECT |
|---|
| Subtitle | |
|---|
| Authors | Ryoichi TANAKA*, Kohei HAYASHIDA*, Yoshiaki HIROSE*, Yoshio ISHIDA*, Kotaroh MIYASHITA**, Tatsuo KAMINAGA***, Tsunehiko NISHIMURA*** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, National Cardiovascular Center, **Department of Neurovasculology, National Cardiovascular Center, ***Department of Tracer Data Analysis, Biomedical Research Center, Osaka University Medical School |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 31 |
|---|
| Number | 9 |
|---|
| Page | 1113-1116 |
|---|
| Year/Month | 1994/9 |
|---|
| Article | Report |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] To standardize the regional cerebral count with 99mTc-HMPAO, equilibrium blood count of which trapping mechanism is the same as the brain was used in seven patients with cerebrovascular disease. We injected 99mTc-HMPAO 740 MBq in 10-15 sec and got sequential arterial sampling in patients who were undertaken with PET. Four hours later 99mTc-HMPAO brain SPECT was taken and a venous sampling was drawn for determining the equilibrium blood count. Correlation between the area of arterial time activity curve and equilibrium venous blood count was 0.93. After 44 regions (36 in cortical area, 8 in deep area) with 99mTc-HMPAO brain SPECT were placed, SPECT counts were corrected by standardization of equilibrium venous blood count. The correlation between rCBF determined from C15O2 PET and corrected SPECT counts was 0.80 and 0.67, cortical area and deep area, respectively. We concluded that 99mTc-HMPAO brain SPECT count can be corrected by equilibrium blood count to standardize the regional cerebral counts. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Quantitative analysis, rCBF, 99mTc-HMPAO, Brain SPECT. |
|---|