| Japanese |
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| Title | 99mTc-GSAによる肝機能評価 - Extraction Indexを用いての検討 - |
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| Subtitle | 原著 |
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| Authors | 橋本順*, 石橋章彦**, 梶谷敏郎**, 栗原孝至**, 深水良哉**, 北洞哲治***, 中村佳代子*, 久保敦司* |
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| Authors(kana) | |
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| Organization | *慶應義塾大学医学部放射線科, **国立大蔵病院放射線科, ***内科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 9 |
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| Page | 1093-1100 |
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| Year/Month | 1994/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-GSAを用いて肝機能を定量的に評価する際の新しい指標として以下の式で表されるExtraction Index(EI5)を考案した. EI5=(L5-L3)/(H3+H5)*PH/PL Ln, Hnはそれぞれ静注後n分における肝臓ROI, 心臓ROI内の総カウントであり, PL, PHは肝臓ROI, 心臓ROI内のピクセル数を表す. 40例の肝疾患患者にGSAを投与して血液データ(ChE, Alb, ZTT, PT, HPT, TB)と各指標との相関を検討した. LHL15とAlb値の相関が高いことを除き, EI5と血液データとの相関は, LHL15, HH15との相関と同等もしくはそれ以上であった. EI5は簡便かつ短時間に算出可能で, 血液データとの相関も良好であり, 実用的な新指標となりうるものと考えられる. またピクセル数で補正してあるために局所の肝機能評価を行いうる可能性も示唆される. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-GSA, Liver scintigraphy, Extraction index. |
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| English |
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| Title | Quantitative Evaluation of Liver Function with 99mTc-GSA Scintigraphy Using Extraction Index |
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| Authors | Jun HASHIMOTO*, Akihiko ISHIBASHI**, Toshiro KAJITANI**, Takashi KURIHARA**, Yoshiya FUKAMIZU**, Tetsuji KITAHORA***, Kayoko NAKAMURA*, Atsushi KUBO* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, School of Medicine, Keio University, **Department of Radiology, ***Department of Internal Medicine, National Okura Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 9 |
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| Page | 1093-1100 |
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| Year/Month | 1994/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Extraction index (EI5) was introduced to evaluate liver function quantitatively with 99mTc-GSA (GSA) scintigraphy, and it was compared with conventional indices; receptor index (LHL15) and clearance index (HH15). EI5 is expressed as following equation: EI5=(L5-L3)/(H3+H5)*PH/PL where L3, L5: counts at 3 or 5 minutes after the injection in the liver ROI, respectively, H3, H5: counts at 3 or 5 minutes in the heart ROI, respectively; PL, PH: numbers of pixels in the liver-and heart-ROI, respectively. We performed GSA scintigraphy in 40 patients with liver dysfunction and calculated values of the indices. Good correlations were observed between EI5 and liver function tests. Correlation coefficients were almost equal to or higher than those between conventional parameters and liver functional tests. EI5 was thought to be a practical index, and it could be calculated in a short time without aid of computer. Evaluation of local liver function may be possible, because EI5 was corrected with numbers of pixels in the liver-and heart-ROI; which was not considered in the conventional parameters. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-GSA, Liver scintigraphy, Extraction index. |
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