Japanese
Title123I-IMP SPECTを用いた簡便な局所脳血流量測定法 (Table look up法およびAutoradiography (ARG) 法) における1回動脈採血の静脈採血代替についての検討
Subtitle原著
Authors伊藤浩*, 赤井沢隆*, 後藤了以*, 小山真道*, 川島隆太*, 小野修一*, 吉岡清郎*, 石井清**, 木下俊文**, 犬飼好政**, 阿部茂人**, 渥美博人**, 佐藤正美**, 福田寛*,
Authors(kana)
Organization*東北大学加齢医学研究所加齢脳神経部門 機能画像医学研究分野, **仙台市立病院放射線科
Journal核医学
Volume31
Number9
Page1071-1076
Year/Month1994/9
Article原著
Publisher日本核医学会
Abstract「要旨」123I-IMP SPECTを用いた簡便な脳血流定量法であるTable look up法およびAutoradiography法では, 標準入力関数を1回動脈採血の全血中放射能濃度で較正して入力関数を求めるが, これを静脈採血で代替可能かどうか検討した. 心肺疾患のない中枢神経系疾患12例および健常者5例の計17例を対象に, 123I-IMP静注後, 動脈および静脈同時採血を経時的に施行した. 静脈/動脈全血中放射能濃度比は静脈採血部位が肘部皮静脈の場合, 静注10分後:0.76±0.08, 20分後:0.80±0.05, 30分後:0.81±0.06, 50分後:0.83±0.11と静脈全血中放射能濃度が動脈全血中放射能濃度に比べ約20%低値であったが, より末梢の皮静脈から採血するほど両者は一致し, 手背部皮静脈では静注10分後:0.93±0.02, 20分後:0.94±0.05, 30分後:0.98±0.04, 50分後:0.98±0.03であった. この場合, CBF測定の誤差を最小にする最適な静脈採血時刻は静注後20分であった.
Practice臨床医学：一般
Keywords123I-IMP, SPECT, Regional CBF, Autoradiography method, Venous blood sampling.
English
TitleA Simple Method for Measurement of Cerebral Blood Flow Using 123I-IMP SPECT with Calibrated Standard Input Function by One Point Blood Sampling ; Validation of Calibration by One Point Venous Blood Sampling as a Substitute for Arterial Blood Sampling
Subtitle
AuthorsHiroshi ITO*, Takashi AKAIZAWA*, Ryoui GOTO*, Masamichi KOYAMA*, Ryuta KAWASHIMA*, Syuichi ONO*, Seiro YOSHIOKA*, Kiyoshi ISHII**, Toshifumi KINOSHITA**, Yoshimasa INUKAI**, Shigeto ABE**, Hiroto ATSUMI**, Masami SATO**, Hiroshi FUKUDA*
Authors(kana)
Organization*Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, **Department of Radiology, Sendai City Hospital
JournalThe Japanese Journal of nuclear medicine
Volume31
Number9
Page1071-1076
Year/Month1994/9
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] In a simplified method for measurement of cerebral blood flow using one 123I-IMP SPECT scan and one point arterial blood sampling (Autoradiography method), input function is obtained by calibrating a standard input function by one point arterial blood sampling. A purpose of this study is validation of calibration by one point venous blood sampling as a substitute for one point arterial blood sampling. After intravenous infusion of 123I-IMP, frequent arterial and venous blood sampling were simultaneously performed on 12 patients of CNS disease without any heart and lung disease and 5 normal volunteers. The radioactivity ratio of venous whole blood which obtained from cutaneous cubital vein to arterial whole blood were 0.76+-0.08, 0.80+-0.05, 0.81+-0.06, 0.83+-0.11 at 10, 20, 30, 50 min after 123I-IMP infusion, respectively. The venous blood radio-activities were always 20% lower than those of arterial blood radioactivity during 50 min. However, the ratio which obtained from cutaneous dorsal hand vein to artery were 0.93+-0.02, 0.94+- 0.05, 0.98+-0.04, 0.98+-0.03, at 10, 20, 30, 50 min after 123I-IMP infusion, respectively. The venous blood radioactivity was consistent with artery. These indicate that arterio-venous difference of radioactivity in a peripheral cutaneous vein like a dorsal hand vein is minimal due to arteriovenous shunt in palm. Therefore, a substitution by blood sampling from cutaneous dorsal hand vein for artery will be possible. Optimized time for venous blood sampling evaluated by error analysis was 20 min after 123I-IMP infusion, which is 10 min later than that of arterial blood sampling.
PracticeClinical medicine
Keywords123I-IMP, SPECT, Regional CBF, Autoradiography method, Venous blood sampling.

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