| Japanese |
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| Title | アドリアマイシン心筋障害における123I-metaiodobenzylguanidine (MIBG) 心筋SPECTの臨床的有用性 |
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| Subtitle | 原著 |
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| Authors | 新津望*, 山崎純一*, 五十嵐正樹*, 梅田正法*, 森下健* |
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| Organization | *東邦大学医学部内科学第一講座 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 9 |
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| Page | 1051-1057 |
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| Year/Month | 1994/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」アドリアマイシン(ADR)を投与した造血器悪性腫瘍患者29例に対し, 123I-metaiodobenzyl-guanidine(MIBG)静注20分後と4時間後に心筋SPECTを撮像した. 得られたMIBG心筋SPECT所見をADR総投与量や心エコー図から算出した左心機能(EF), 左室壁運動などと比較検討した. ADR総投与量は平均329.3mg/m2(150〜550mg/m2)であった. DADR投与を受けMIBG心筋SPECTで異常が認められた症例(75%)では, 心機能が維持されているにもかかわらずwashout rate(WR)が高値を示し, 交感神経障害の存在が示唆された. 2)ADR総投与量とMIBGのWRとの間に有意な(p<0.001)相関関係が認められたことから, WRはEFより心筋の交感神経障害の早期の指標となると考えられた. 3)ADR心筋障害の発生機序の一因として, 交感神経障害の関与が示唆された. 以上より, MIBGはADRの投与量および投与方法選択の一助となる検査法と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Adriamycin-induced cardiomyopathy, 123I-metaiodobenzylguanidine, Washout rate, Ejection fraction. |
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| English |
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| Title | Clinical Usefulness of 123I-MIBG Myocardial SPECT in Patients with Adriamycin-Induced Cardiomyopathy |
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| Subtitle | Original Articles |
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| Authors | Nozomi NIITSU, Junichi YAMAZAKI, Masaki IGARASHI, Masanori UMEDA, Takeshi MORISHITA |
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| Authors(kana) | |
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| Organization | First Department of Internal Medicine, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 9 |
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| Page | 1051-1057 |
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| Year/Month | 1994/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In 29 patients who had been administrated adriamycin (ADR) for the treatment of hematopoietic malignancies, myocardial SPECT was performed 20 minutes and 4 hours after an intravenous dose of 123I-metaiodobenzylguanidine (MIBG). Findings of the myocardial SPECT were compared with the total dose of ADR, ejection fraction (EF) and left ventricular wall motion, as assessed by ultrasound echocardiography. The mean total dose of ADR was 329.3 mg/m2 (range, 150-550mg/m2). 1) Although the cardiac function was normal, the washout rate (WR) of MIBG was high in 75% of the patients whose MIBG myocardial SPECT showed abnormality on ADR, suggesting the presence of adrenergic nerve disorder. 2) The total dose of ADR was significantly correlated with WR of MIBG (p<0.001). Consequently, WR of MIBG may be an index which reflects adrenergic nerve disorder in the myocardium earlier than EF. 3) It was suggested that adrenergic nerve disorder was involved in pathogenesis of myocardial complications associated with ADR administration. In summary, MIBG myocardial SPECT could be a useful test for determining a dosage regimen of ADR therapy of individual patients. |
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| Practice | Clinical medicine |
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| Keywords | Adriamycin-induced cardiomyopathy, 123I-metaiodobenzylguanidine, Washout rate, Ejection fraction. |
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