| Japanese |
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| Title | 18F-FDG PETを用いた心筋糖代謝の非侵襲的な定量化の試み |
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| Subtitle | 技術報告 |
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| Authors | 高橋範雄*,****, 玉木長良*, 河本雅秀*, 間賀田泰寛*, 奥田和美**, 野原隆司**, 篠山重威**, 米倉義晴***, 小西淳二*, 山本和高****, 石井靖**** |
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| Authors(kana) | |
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| Organization | *京都大学医学部核医学科, **第三内科, ***脳病態生理学, ****福井医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 8 |
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| Page | 985-990 |
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| Year/Month | 1994/8 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患患者14例を対象にFDGを用いたdynamic PETを施行し, PET画像上の左室, 左房, および大動脈に関心領域を設定し得られたtime activity curve(TAC)を, 同時に施行した動脈採血によるTACと比較した. 全血と血漿中のFDGの比は経時的変動が少なく, かつ個体間でもばらつきが少なく, 7例の平均である0.91(±0.02)でPET画像上の全血の値を血漿の値に補正可能と考えられた. いずれの血液プールのカウントも採血の値を基準とすると, 心筋集積からのspill overのために経時的増加傾向がみられた. しかし, それぞれをinput functionとしPatlak Plot法により求めたk1k3/(k2+k3)は採血による値と非常に良好な相関を認め(左室r=0.95, 左房r=0.96, 大動脈r=0.98), 動脈採血を不要としたより簡便で非侵襲的な心筋糖代謝の定量化が可能であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron emission tomography, Myocardial glucose metabolism, Ischemic heart disease, Patlak graphic analysis, Fluorodeoxy-glucose. |
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| English |
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| Title | Noninvasive and Simple Method for the Estimation of Myocardial Metabolic Rate of Glucose by PET and 18F-FDG |
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| Authors | Norio TAKAHASHI*,****, Nagara TAMAKI*, Masahide KAWAMOTO*, Yasuhiro MAGATA*, Kazumi OKUDA**, Ryuji NOHARA**, Shigetake SASAYAMA**, Yoshiharu YONEKURA***, Junji KONISHI*, Kazutaka YAMAMOTO****, Yasushi ISHII**** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Third Division, Department of Internal Medicine, ***Department of Brain Pathophysiology, Kyoto University Faculty of Medicine, ****Department of Radiology, Fukui Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 8 |
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| Page | 985-990 |
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| Year/Month | 1994/8 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To estimate regional myocardial metabolic rate of glucose (rMRGlu) with positron emission tomography (PET) and 2-[18F]fluoro-2-deoxy-D-glucose (FDG), non invasive simple method has been investigated using dynamic PET imaging in 14 patients with ischemic heart disease. This imaging approach uses a blood time-activity curve (TAC) derived from a region of interest (ROI) drawn over dynamic PET images of the left ventricle (LV), left atrium (LA) and aorta. Patlak graphic analysis was used to estimate k1k3/(k2+k3) from serial plasma and myocardial radioactivities. FDG counts ratio between whole blood and plasma was relatively constant (0.91+-0.02) both throughout the time and among different patients. Although TACs derived from dynamic PET images gradually increased at later phase due to spill over from the myocardium into the cavity, there were good agreements between the estimated K complex values obtained from arterial blood sampling and dynamic PET imaging (LV r=0.95, LA r=0.96, aorta r=0.98). These results demonstrate the practical usefulness of a simplified and noninvasive method for the estimation of rMRGlu in humans by PET. |
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| Practice | Clinical medicine |
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| Keywords | Positron emission tomography, Myocardial glucose metabolism, Ischemic heart disease, Patlak graphic analysis, Fluorodeoxy-glucose. |
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