| Japanese |
|---|
| Title | 心筋viability評価法としてのニトログリセリン舌下併用201Tl再静注法の試み |
|---|
| Subtitle | 原著 |
|---|
| Authors | 宮川正男*, 熊野正士*, 関谷達人**, 渡辺浩毅**, 橋田啓**, 塩出昌弘**, 西村一孝**, 阿久津弘**, 井町恒雄***, 棚田修二****, 濱本研**** |
|---|
| Authors(kana) | |
|---|
| Organization | *国立療養所愛媛病院放射線科, **内科, ***外科, ****愛媛大学医学部放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 31 |
|---|
| Number | 8 |
|---|
| Page | 943-950 |
|---|
| Year/Month | 1994/8 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」虚血性心疾患80例につき, 従来の運動負荷201Tl心筋SPECT少量再静注法を施行した40例と再静注直前にニトログリセリン舌下を併用した40例との間で再分布の程度を比較し, ニトログリセリン併用法の有用性を検討した. ニトログリセリン舌下群においてSPECT後期像の200区域中, 固定性欠損は50区域に存在し, そのうち再静注像にてfill inが認められたのは21区域(42%)であった. 一方, 非舌下群では後期像で固定性欠損は51区域に存在したが, 再静注像でのfill inは16区域(31%)とニトログリセリン舌下群に比して低率であった. また, 後期像において不完全再分布を示した区域に再静注像でfill inを認めた割合は, 非舌下群の17/42(41%)に対し, ニトログリセリン舌下群では22/44(50%)と高率であった. また, 側副血行支配領域において201Tlのfill inを認めた区域数の割合は, 非舌下群に比しニトログリセリン舌下群で有意に大であった(p<0.05). これらの結果から, ニトログリセリン舌下再静注法は, 従来法による心筋viabilityの過小評価を防止する有用な方法であることが示唆された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Coronary artery disease, Thallium-201, Myocardial viability, Reinjection scan, Nitroglycerin. |
|---|
| English |
|---|
| Title | Assessment of Myocardial Viability by Thallium-201 Reinjection Imaging with Sublingual Nitroglycerin |
|---|
| Subtitle | |
|---|
| Authors | Masao MIYAGAWA*, Seishi KUMANO*, Michihito SEKIYA**, Kouki WATANABE**, Kei HASHIDA**, Masahiro SHIODE**, Kazutaka NISHIMURA**, Hiroshi AKUTSU**, Tsuneo IMACHI***, Shuji TANADA****, Ken HAMAMOTO**** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, **Department of Internal Medicine, ***Department of Surgery, Ehime National Hospital, ****Department of Radiology, Ehime University School of Medicine |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 31 |
|---|
| Number | 8 |
|---|
| Page | 943-950 |
|---|
| Year/Month | 1994/8 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Although thallium-201 (201Tl) reinjection imaging improves the detection of myocardial viability compared to standard 3-4-hr redistribution (RD) imaging, it still underestimates the extent of viable myocardium. We examined whether 201Tl reinjection SPECT with sublingual nitroglycerin (NTG) had a higher sensitivity for viability detection than reinjection alone. Eighty patients with coronary artery disease were studied, 38 of them with an old myocardial infarction. At the peak of exercise, 111MBq 201Tl was injected and the initial and the delayed SPECT images were obtained. Then, all patients were divided randomly into two groups, and in each group, SPECT data were obtained again after the injection of 37 MBq 201Tl with (NTG (+) group) or without 0.6 mg of sublingual NTG (NTG (-) group). Among 50 segments showing fixed defects on the delayed image in the NTG (+) group, 21 (42%) were found to be reversible on the reinjection image, as compared to 16 of 51 (31%) in the NTG (-) group. Twenty-two of 44 (50%) segments showing incomplete RD were found to be reversible in the NTG (+) group, while 17 of 42 (41%) segments in the NTG (-) group. Moreover, the ratio of reversible segments seen in the reinjection images was significantly higher in the collateralized regions of the NTG (+) group than in those of the NTG (-) group (20/26 vs. 14/28, p<0.05). Thus, 201Tl reinjection SPECT with sublingual NTG improves the detection of ischemic but viable myocardium as compared to SPECT with reinjection alone. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Coronary artery disease, Thallium-201, Myocardial viability, Reinjection scan, Nitroglycerin. |
|---|