| Japanese |
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| Title | アデノシン三リン酸二ナトリウム (ATP) 負荷タリウム心筋シンチグラフィの診断能および副作用 - 虚血性心疾患における冠動脈有意狭窄病変の診断能 - |
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| Subtitle | 原著 |
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| Authors | 木下信一郎*, 鈴木成雄*, 進藤晃*, 渡辺圭子*, 村松俊裕*, 井出雅生*, 土肥豊*, 山下三朗**, 鈴木哲男***, 西村克之****, 宮前達也**** |
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| Authors(kana) | |
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| Organization | *埼玉医科大学第二内科, **小川赤十字病院内科, ***富士吉田市立病院内科, ****埼玉医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 8 |
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| Page | 935-941 |
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| Year/Month | 1994/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」ATP負荷タリウム心筋シンチグラフィの至適投与量, 診断能, 副作用出現頻度について172名の虚血性心疾患患者を対象に検討した. 診断能は冠動脈造影を施行した111名全体で感度87.5%, 特異度83.9%, 診断精度86.5%であった. ATP 0.16mg/kg投与群は感度92.2%, 特異度81.3%, 診断精度89.6%であり, 0.18mg/kg投与群は感度79.3%, 特異度86.7%, 診断精度81.8%であった(p=NS). 副作用出現度は, 172名中144名, 83.7%に出現した. 胸痛が最も多く, 次いで紅潮感, ST低下などが出現した. 0.16mg投与群では88.6%, 0.18mg投与群では74.6%に出現した(p=NS). しかし, すべての副作用はATP投与終了2分以内に消失し, いずれの症例も治療を要さなかった. 投与量については, 体重1kg当たり1分間0.16mgが至適量と考えられた. ATP負荷タリウム心筋シンチグラフィは虚血性心疾患診断に有効で, その安全性は高いと認められた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Coronary artery disease, ATP, Thallium myocardial scintigraphy, Pharmacologic stress, Diagnostic efficiency. |
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| English |
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| Title | The Accuracy and Side Effects of Pharmacologic Stress Thallium Myocardial Scintigraphy with Adenosine Triphosphate Disodium (ATP) Infusion in the Diagnosis of Coronary Artery Disease |
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| Subtitle | Original Articles |
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| Authors | Shinichiro KINOSHITA*, Shigeo SUZUKI*, Akira SHINDOU*, Keiko WATANABE*, Toshihiro MURAMATSU*, Masao IDE*, Yutaka DOHI*, Saburou YAMASHITA**, Tetsuo SUZUKI***, Katsuyuki NISHIMURA****, Tatsuya MIYAMAE**** |
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| Authors(kana) | |
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| Organization | *Second Department of Internal Medicine, Saitama Medical School, **Department of Internal Medicine, Ogawa Red Cross Hospital, ***Department of Internal Medicine, Fujiyoshida Municipal Hospital, ****Department of Radiology, Saitama Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 8 |
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| Page | 935-941 |
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| Year/Month | 1994/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The diagnostic accuracy and side effects of pharmacologic stress thallium myocardial scintigraphy with ATP infusion were studied in 172 patients with or without coronary artery disease. ATP was infused for five minutes at a rate of 0.16mg/kg/min (group A) or 0.18 mg/kg/min (group B) via antecubital vein. One hundred and eleven (67 of group A, 44 of group B) of 172 patients underwent coronary arteriography (CAG). In 111 patients received CAG, overall sensitivity, specificity and accuracy of this method were 88%, 84% and 87%, respectively. In 67 patients of group A, these were 92%, 81% and 90%. In 44 patients of group B, 79%, 87% and 82% were documented (NS, between group A and B). Chest pain, flushing, bradycardia and ST depression were included in side effects caused by ATP infusion. At least one of these side effects were observed in 84% of the all 172 patients, 89% of group A and 75% of group B (NS). But, all of the side effects were spontaneously alleviated within two minutes without any therapy. In conclusion, pharmacologic stress myocardial scintigraphy with ATP infusion is very accurate and safe, and infusion rate of 0.16mg/kg/min is optimal for this purpose. |
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| Practice | Clinical medicine |
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| Keywords | Coronary artery disease, ATP, Thallium myocardial scintigraphy, Pharmacologic stress, Diagnostic efficiency. |
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