Japanese
Title陳旧性心筋梗塞例における脂肪酸代謝イメージングの評価 : 定量的解析による検討
Subtitle原著
Authors松成一朗*, 一柳健次*, 滝淳一**, 中嶋憲一**, 西川高広***, 利波紀久**, 久田欣一**
Authors(kana)
Organization*福井県立病院放射線科, **金沢大学医学部核医学科, ***金沢医科大学医学部放射線科
Journal核医学
Volume31
Number8
Page927-933
Year/Month1994/8
Article原著
Publisher日本核医学会
Abstract「要旨」陳旧性心筋梗塞例における脂肪酸代謝を定量的に評価した. 発症後1か月以上経過した心筋梗塞20例に, 運動負荷201Tl, 安静時BMIPPイメージングを施行した. 左室心筋を20領域に分割し, 最高カウントを示す領域を100%とした相対的集積を算出した. また, 運動負荷201Tlに基づき, 各領域を正常群, 可逆性欠損群, 固定性欠損群, 逆両分布を伴う欠損群に分類し, 201Tl像とBMIPP像との比較を定量的に施行した. さらに洗い出し率を求めた. BMIPP20分後像の欠損は, 201Tl3時間後像より高度であった(p<0.001). 特に負荷201Tlで可逆性欠損を示す領域群では201Tl3時間後像に比しBMIPP集積低下を高率に認めた(45%). BMIPP 20分後像と3時間後像との比較では17%の領域にFill-inを認め, 可逆性欠損群の洗い出し率(-1.6±13.9%)は, 正常群(9.0±9.8%), 固定性欠損群(3.8±12.9%)に比し低値であった. BMIPPシンチグラフィにより, 虚血心筋の詳細な情報を得ることが可能と思われた.
Practice臨床医学：一般
Keywords123I-labeled 15-(p-iodophenyl)3R, S-methylpentadecanoic acid, SPECT, Old myocardial infarction, Exercise 201Tl.
English
TitleQuantitative Analysis of 123I-BMIPP Imaging in Relation to Exercise-Redistribution 201Tl in Patients with Old Myocardial Infarction
SubtitleOriginal Articles
AuthorsIchiro MATSUNARI*, Kenji ICHIYANAGI*, Junichi TAKI**, Ken-ichi NAKAJIMA**, Takahiro NISHIKAWA***, Norihisa TONAMI**, Kinichi HISADA**
Authors(kana)
Organization*Department of Radiology, Fukui Prefectural Hospital, **Department of Nuclear Medicine, Kanazawa University, School of Medicine, ***Department of Radiology, Kanazawa Medical School
JournalThe Japanese Journal of nuclear medicine
Volume31
Number8
Page927-933
Year/Month1994/8
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Myocardial kinetics of 123I-labeled 15-(p-iodophenyl) 3R, S-methylpentadecanoic acid (BMIPP) was evaluated with BMIPP imaging in conjunction with stress-201Tl. We studied 20 patients with old myocardial infarction. BMIPP SPECT was obtained at 20 min and 3 h after injection. On a separate day, exercise stress-201Tl SPECT was performed at 10 min and 3 h after injection. Then, left ventricular myocardium was divided into 20 segments. For quantitative analysis, in each SPECT data, the maximum value (average counts per pixel) of all 20 myocardial segments was taken as 100%; the other values were calculated as a percentage of this maximum (Relative regional uptake, RRU). On the basis of stress-201Tl pattern, the myocardial segments were classified into 4 groups; normal 201Tl uptake, reversible 201Tl defect, fixed 201Tl defect and 201Tl defect with reverse redistribution. The 20 min BMIPP showed reduced activity compared with 3 h-201Tl (p<0.001), especially in the area of 201Tl redistribution (50/111segments, 45%), implicating impaired fatty acid utilization at resting condition. The washout rate of the segments with reversible 201Tl defect (-1.6+-13.9%) was significantly lower than that of the segments with normal 201Tl uptake (9.0+-9.8%) and fixed 201Tl defect (3.8+-12.9%). Thus, BMIPP in combination with stress 201Tl imaging provides precise informations of impaired myocardial fatty acid utilization in patients with old myocardial infarction.
PracticeClinical medicine
Keywords123I-labeled 15-(p-iodophenyl)3R, S-methylpentadecanoic acid, SPECT, Old myocardial infarction, Exercise 201Tl.

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