| Japanese |
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| Title | 塵肺における123I-IMP肺クリアランスの検討 |
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| Subtitle | 原著 |
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| Authors | 石野洋一*, 中田肇* |
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| Authors(kana) | |
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| Organization | *産業医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 8 |
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| Page | 921-926 |
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| Year/Month | 1994/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」健康な非喫煙者5例と塵肺患者10例を対象に123I-IMP肺シンチグラフィを行い, その肺内動態を比較検討した. 123I-IMP静注後50分間ダイナミックデータを収集し, 両肺野全体を関心領域として, その時間放射能曲線をC(t)=A1e-k1t+A2e-k2tの2コンパートメントモデルにて解析した. その結果, 塵肺症例では健常症例に比し明らかに123I-IMPの洗い出し遅延を認め, 特に早期洗い出し率であるk1が有意に低値を示した. 投与後早期の洗い出し遅延は, 高度の線維性変化に伴うびまん性の肺血流低下を反映しているものと思われた. 67Gaシンチグラフィにおける肺集積程度とは関連がみられたが各種肺機能指標とは明らかな相関を認めなかった. 123I-IMP肺シンチグラフィにおける肺洗い出し曲線は塵肺による肺障害を客観的, 定量的に評価することが可能で, 胸部単純X線検査や肺機能検査を補う意味で臨床的に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, Time activity curve, Pneumoconiosis. |
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| English |
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| Title | 123I-IMP Clearance of the Lung in Pneumoconiosis |
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| Subtitle | Original Articles |
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| Authors | Yoichi ISHINO, Hajime NAKATA |
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| Authors(kana) | |
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| Organization | Department of Radiology, University of Occupational and Environmental Health, School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 8 |
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| Page | 921-926 |
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| Year/Month | 1994/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We studied 123I-IMP lung clearance on 10 cases of pneumoconiosis and compared it with the data of 5 non-smoking young adults. After the venous injection of 111 MBq of 123I-IMP we collected the lung dynamic data using 1 frames/10 sec for 10 minutes and 1 frame/min for following 40 minutes. The time activity curve after the injection of 123I-IMP was Obtained as follows: C(t)=A1e-k1t+A2e-k2t (k1, k2: slopes of the exponential component at the early and delayed phase). The 123I-IMP clearance was delayed in the patients group especially on the early phase and the k1 was lower than that of the normal group. Our results indicate that the pulmonary blood flow of the patients with pneumoconiosis decreased because of the advanced fibrotic change. This dynamic analysis may prove useful for the evaluation of the pneumoconiosis objectively and quantitatively. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, Time activity curve, Pneumoconiosis. |
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