| Japanese |
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| Title | ポジトロン断層装置を用いた神経賦活試験のための統合全自動化されたデータ解析法の開発とその応用 |
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| Subtitle | 原著 |
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| Authors | 蓑島聡*,**, Robert A.KOEPPE**, David E.KUHL**, 有水昇* |
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| Organization | *千葉大学医学部放射線科, **Division of Nuclear Medicine, Department of Internal Medicine, The University of Michigan |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 8 |
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| Page | 891-908 |
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| Year/Month | 1994/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」15O水を用いたポジトロン断層装置による神経賦活試験のための統合されたデータ解析法を開発した. この統合された方法は, 被検者内頭位移動補正法, 脳正中矢状断検出法, 交連間線検出法, 線形および非線形脳解剖標準化法, 画素ごとの統計学的検討, 画像表示法を含み, 解析はすべて3次元空間でなされ, また全自動化されている. それぞれの方法について, 脳ファントム, 画像シミュレーション, および被検者より得たデータを用いてその精度と信頼性が高いことを確認した. さらにこの解析法を用いて, 正常被検者より得た振動覚, 視覚刺激試験を解析した結果, 一次感覚野の有意な血流増加に加え, 二次感覚野および小脳等での血流増加を検出することができた. 提案する統合全自動化された方法が, ポジトロン断層装置を用いた神経賦活試験を普及させ, またより高次の脳機能解明を促進することが期待される. |
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| Practice | 臨床医学：一般 |
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| Keywords | Emission computed tomography, Brain mapping, Neuronal activation, Cerebral blood flow, Image processing. |
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| English |
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| Title | Integrated and Automated Data Analysis for Neuronal Activation Studies Using Positron Emission Tomography : Methodology and Applications |
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| Subtitle | Original Articles |
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| Authors | Satoshi MINOSHIMA*,**, Robert A.KOEPPE**, David E.KUHL**, Noboru ARIMIZU* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Chiba University School of Medicine, **Division of Nuclear Medicine, Department of Internal Medicine, The University of Michigan |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 8 |
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| Page | 891-908 |
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| Year/Month | 1994/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A data analysis method was developed for neuronal activation studies using [15O] water positron emission tomography (PBT). The method consists of several procedures including intra-subject head motion correction (co-registration), detection of the mid-sagittal plane of the brain, detection of the intercommissural (AC-PC) line, linear scaling and non-linear warping for anatomical standardization, pixel-by-pixel statistical analysis, and data display. All steps are performed in three dimensions and are fully automated. Each step was validated using a brain phantom, computer simulations, and data from human subjects, demonstrating accuracy and reliability of the procedure. The method was applied to human neuronal activation studies using vibratory and visual stimulations. The method detected significant blood flow increases in the primary sensory cortices as well as in other regions such as the secondary sensory cortex and cerebellum. The proposed method should enhance application of PET neuronal activation studies to the investigation of higher-order human brain functions. |
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| Practice | Clinical medicine |
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| Keywords | Emission computed tomography, Brain mapping, Neuronal activation, Cerebral blood flow, Image processing. |
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