| Japanese |
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| Title | 99mTc-HMPAOによる薬剤誘起性肺損傷の検出 |
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| Subtitle | 原著 |
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| Authors | 菅一能*, 内迫博路*, 西垣内一哉*, 久米典彦*, 塚本勝彦*, 粟屋ひとみ*, 中西敬* |
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| Authors(kana) | |
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| Organization | *山口大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 31 |
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| Number | 6 |
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| Page | 581-591 |
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| Year/Month | 1994/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」薬剤誘起性肺損傷の99mTc-hexamethylpropyleneamine oxime(99mTc-HMPAO)による検出を, オレイン酸少量投与(0.05ml/kg)し軽微な肺障害を有する家兎で基礎的検討し, さらに臨床的に抗癌剤投与例で検討した. オレイン酸少量(0.05ml/kg)投与した家兎肺は胸部X線写真や病理組織の光顕像では変化に乏しく, 電顕像で肺血管内皮細胞の障害が把握されたが, 99mTc-HMPAOはびまん性にコントロール群に比し高い肺集積を示した. この高い肺集積は静注後1分以内の早期に起きた. これに対し, 99mTc-MAA肺血流シンチグラフィや99mTc-DTPA肺シンチグラフィは異常集積を示さなかった. さらにオレイン酸の投与量の増加に伴い99mTc-HMPAOの肺集積の程度は高くなった. 臨床的には抗癌剤投与群は非投与群に比較して高い肺集積を示し, このうち最も高い集積を示した症例は後に化学療法によると考えられるびまん性の浸潤影を呈した. これらの所見は99mTc-HMPAOが薬剤誘起性肺損傷の検出に鋭敏なマーカーで臨床例でも肺損傷の検出に応用可能なことを示唆した. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-HMPAO, Diffuse pulmonary uptake, Anti-cancer drugs, Oleic acid. |
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| English |
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| Title | Experimental and Clinical Evaluation of 99mTc-HMPAO as a Sensitive Marker for Chemical Lung Injury |
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| Subtitle | Original Articles |
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| Authors | Kazuyoshi SUGA, Hiromichi UCHISAKO, Kazuya NISHIGAUCHI, Norihiko KUME, Katsuhiko TSUKAMOTO, Hitomi AWAYA, Takashi NAKANISHI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Yamaguchi University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 31 |
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| Number | 6 |
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| Page | 581-591 |
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| Year/Month | 1994/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To investigate whether 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) can be a sensitive marker of lung injury, an animal model of lung injury was designed in the rabbits using the injection of a low dose (0.05ml/kg) of oleic acid. In the injured rabbit lungs, electron microscope revealed morphologic changes localized in the microvascular endothelium (edematous change), although their chest radiographies and light microscope did not show any significant changes compared to the controls. In these situations, 99mTc-HMPAO Showed a diffusely, high pulmonary uptake, which occurred rapidly within the first l min after the injection. Clinically, the lungs in the patients who had been administered with cytotoxic anti-cancer drugs showed a significantly higher 99mTc-HMPAO uptake compared to the controls. These findings indicate that 99mTc-HMPAO may have potential as a sensitive marker of chemical lung injury. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-HMPAO, Diffuse pulmonary uptake, Anti-cancer drugs, Oleic acid. |
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